[CAS NO. 470-67-7]??1,4-Cineole

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PRODUCTS SPECIFICATIONS [470-67-7]

Catalog

HY-N7117

Brand

MCE

CAS

470-67-7

DESCRIPTION [470-67-7]

Overview

MDL	MFCD00209502
Molecular Weight	154.25
Molecular Formula	C10H18O
SMILES	CC(C12CCC(O2)(C)CC1)C

For research use only. We do not sell to patients.

Summary

1,4-Cineole is a widely distributed, natural, oxygenated monoterpene ^[1] . 1,4-Cineole, present in Rhododendron anthopogonoides , activates both human TRPM8 and human TRPA1 ^[2] .

IC50 & Target

Human Endogenous Metabolite

Appearance

Liquid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 810.37 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4830 mL	32.4149 mL	64.8298 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (13.48 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (13.48 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (13.48 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6.
[2] Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

Synonyms

7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-

p-Menthane, 1,4-epoxy-

7-Oxabicyclo[2.2.1]heptane, 1-isopropyl-4-methyl-

1-Methyl-4-(1-methylethyl)-7-oxabicyclo[2.2.1]heptane

1,4-Cineole

Isocineole

1,4-Cineol

1-Methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane

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