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| | (D-ALA2)-LEUCINE ENKEPHALIN-ARG Basic information |
| Product Name: | (D-ALA2)-LEUCINE ENKEPHALIN-ARG | | Synonyms: | L-Tyr-D-Ala-Gly-L-Phe-L-Leu-L-Arg-OH;1-6-beta-Neoendorphin (human), 2-D-alanine-;2-D-Alanine-1-6-beta-neoendorphin (human);Brn 4287455;L-Arginine, N(sup 2)-(N-(N-(N-(L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-;N(Sup 2)-(N-(N-(N-(L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginine;Tageflar;Dalargin,(D-Ala2)-Leu-Enkephalin-Arg | | CAS: | 81733-79-1 | | MF: | C35H51N9O8 | | MW: | 725.83 | | EINECS: | | | Product Categories: | | | Mol File: | 81733-79-1.mol |  |
| | (D-ALA2)-LEUCINE ENKEPHALIN-ARG Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | pka | 3.34±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | (D-ALA2)-LEUCINE ENKEPHALIN-ARG Usage And Synthesis |
| Uses | Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity[1][2][3]. | | in vivo | Dalargin (25, 50 μg/kg; i.p.) shows nephroprotective effects on gentamicin-induced kidney injury in rats[2]. | Animal Model: | 290-350 g, White male rats[2] | | Dosage: | 25, 50 μg/kg | | Administration: | I.p. (3 h before each gentamicin injection) | | Result: | Mitigated gentamicin-induced acutekidney injury, attenuated ROS generation and oxidative stress, alleviated histopathological changes in a renal tissue. |
| | IC 50 | δ Opioid Receptor/DOR | | References | [1] Titov MI, et al. Dalargin--a peptidny preparat s tsitoprotektivnym destviem [Dalargin--a peptide preparation with cytoprotective action]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8(2):72-6. PMID:2998416
[2] Plotnikov EY, et al. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity. Toxicol Lett. 2013 Jul 18;220(3):303-8. DOI:10.1016/j.toxlet.2013.04.023
[3] Polonski VM, et al. Mesto prilozheniia (tsentral'noe ili perifericheskoe) protivoiazvennogo destviia sinteticheskogo analoga éndogennykh opioidov dalargina v éksperimental'no modeli tsisteaminovykh duodenal'nykh iazv u krys [The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats]. Biull Eksp Biol Med. 1987 Apr;103(4):433-4. PMID:3032303 |
| | (D-ALA2)-LEUCINE ENKEPHALIN-ARG Preparation Products And Raw materials |
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