MOLINDONE HYDROCHLORIDE (500 MG) manufacturers
|
| | MOLINDONE HYDROCHLORIDE (500 MG) Basic information |
| Product Name: | MOLINDONE HYDROCHLORIDE (500 MG) | | Synonyms: | Lindone;Molindone Hydrochlorid;4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-Methyl-5-(4-MorpholinylMethyl)-, Monohydrochloride;3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-1H-indol-4(5H)-one Hydrochloride
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one Hydrochloride;3-ethyl-6,7-dihydro-2-methyl-5-morpholinomethylindole-4(5h)-onehydrochloride;lidone;moban;Indol-4(5H)-one,3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-,monohydrochloride | | CAS: | 15622-65-8 | | MF: | C16H25ClN2O2 | | MW: | 312.84 | | EINECS: | | | Product Categories: | Heterocycles;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 15622-65-8.mol |  |
| | MOLINDONE HYDROCHLORIDE (500 MG) Chemical Properties |
| Melting point | 211-213°C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: soluble19mg/mL | | form | solid | | color | off-white | | Merck | 14,6233 | | Major Application | pharmaceutical | | InChI | 1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H | | InChIKey | GQWNECFJGBQMBO-UHFFFAOYSA-N | | SMILES | CCC1=C(C)NC2=C1C(C(CN3CCOCC3)CC2)=O.Cl |
| Hazard Codes | Xn | | Risk Statements | 22 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | NM3325000 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 2934990002 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral | | Toxicity | LD50 orally in rats: 261 mg/kg (Goldenthal) |
| | MOLINDONE HYDROCHLORIDE (500 MG) Usage And Synthesis |
| Chemical Properties | Light Tan Solid | | Originator | Moban,Endo,US,1974 | | Uses | Antipsychotic;Dopamine receptor antagonist | | Uses | D2 Dopamine receptor antagonist. MAO inhibitor. Antipsychotic. | | Definition | ChEBI: Molindone hydrochloride is a member of indoles. | | Manufacturing Process | Diethyl ketone may be reacted with methyl nitrite and that product in turn reacted with cyclohexan-1,3-dione to give 3-ethyl-4,5,6,7-tetrahydro-2-
methyl-4-oxoindole.
3-ethyl-4,5,6,7-tetrahydro-2-methyl-4-oxoindole 14.1 g (0.08 mol), 14.8 g
morpholine hydrochloride (0.12 mol), and 3.6 g paraformaldehyde (0.12 mol)
were refluxed in 200 ml ethanol for 40 hours. The solution was evaporated to
dryness in vacuo on a steam bath and the residue digested with a mixture of
150 ml water and 10 ml 2N HCl. An insoluble residue of unreacted starting
material was filtered off. To the acid solution, ammonia water was added
dropwise with stirring and the amine crystallized out. It was purified by
dissolving in 1N HCl and addition of ammonia, then by 2 crystallizations from
benzene followed by 2 crystallizations from isopropanol, to yield 3-ethyl-
4,5,6,7-tetrahydro-2-methyl-4-oxoindole, melting point 180°C to 181°C. | | Brand name | Moban (Endo). | | Therapeutic Function | Antipsychotic | | Biological Activity | D2 dopamine receptor antagonist; MAO inhibitor. | | References | [1] Patent: CN107011237, 2017, A. Location in patent: Paragraph 0039-0048 |
| | MOLINDONE HYDROCHLORIDE (500 MG) Preparation Products And Raw materials |
|