ARV110 manufacturers
- ARV110
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2026-07-30
- CAS:2222112-77-6
- Min. Order: 1gram
- Purity: 98%
- Supply Ability: 100
- Bavdegalutamide
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- $132.00
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2026-07-27
- CAS:2222112-77-6
- Purity: 99.79%
- Supply Ability: 10g
- ARV110
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2026-07-06
- CAS:2222112-77-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| Product Name: | ARV110 | | Synonyms: | 3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-;N-((1R,4R)-4-(3-chloro-4-cyanophenox
y)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopip
eridin-3-yl)-6-fluoro-1,3-dioxoisoindoli
n-5-yl)piperazin-1-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide;N-(trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide;Bavdegalutamide (ARV-110);3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]...;prostate,castration-resistant prostate cancer,receptor,ARV 110,androgen,Bavdegalutamide,Androgen Receptor,inhibit,cancer,ARV110,Inhibitor,metastatic;Bavdegalutamide (ARV-110) ，S6965;N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide | | CAS: | 2222112-77-6 | | MF: | C41H43ClFN9O6 | | MW: | 812.29 | | EINECS: | | | Product Categories: | | | Mol File: | 2222112-77-6.mol |  |
| | ARV110 Chemical Properties |
| Boiling point | 1074.1±65.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at-20°C, away from moisture | | solubility | DMSO : 26.67 mg/mL (32.83 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C) | | pka | 10.59±0.40(Predicted) | | form | Solid | | color | Light yellow to yellow | | InChIKey | CLCTZVRHDOAUGJ-SYVGMNBRSA-N | | SMILES | C1(C(N[C@@H]2CC[C@@H](OC3=CC=C(C#N)C(Cl)=C3)CC2)=O)=NN=C(N2CCC(CN3CCN(C4C(F)=CC5=C(C=4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C=C1 |
| | ARV110 Usage And Synthesis |
| Description | ARV-110 is an androgen receptor PROTAC degrader. It promotes ubiquitination and degradation of the androgen receptor. | | Characteristics | ARV-110 is a PROteolysis TArgeting Chimera (PROTAC) protein degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the polyubiquitination and subsequent proteasomal degradation of AR. It selectively degrades wild-type AR and most clinically relevant mutants with low nanomolar potency.
| | Uses | Bavdegalutamide (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. Bavdegalutamide promotes ubiquitination and degradation of AR. Bavdegalutamide can be used for the research of prostate cancer (Pink: AR ligand (HY-168299); Blue: E3 ligase ligand (HY-W093272); Black: linker (HY-W091986))[1]. | | in vivo | Bavdegalutamide (oral gavage; 1 mg/kg; QD) exhibits a greater than 90% AR degradation in vivo. In LNCaP, VCaP and prostate cancer patient derived xenograft (PDX) models, Bavdegalutamide also exhibits significant inhibition of tumor growth and AR signaling[2].Bavdegalutamide (oral gavage; 3 or 10 mpk; 30 days) demonstrates in vivo efficacy and reduction of AR-target gene expression in a long term, castrate, enzalutamide-resistant VCaP tumor model. The TGI are 70% and 60% for 3 mpk and 10 mpk dosage. Respectively[2]. | | References | [1] Taavi Neklesa, et al. ARV-110: An androgen receptor PROTAC degrader for prostate cancer. American Association for Cancer Research. 2018. 78 (13): pp. 5236.
[2] Taavi K Neklesa,et al. ARV-110: an oral androgen receptor PROTAC degrader for prostate cancer. GU ASCO 2019 |
| | ARV110 Preparation Products And Raw materials |
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