2-甲基-2,6-壬二烯-1-胺
| 中文名稱 | 2-甲基-2,6-壬二烯-1-胺 |
|---|---|
| 中文同義詞 | 2-甲基-2,6-壬二烯-1-胺;6-壬二烯-1-胺;N-(26-二甲基苯基)-1-甲基哌啶-2-甲酰胺;美哌卡因;N-(2,6-二甲基苯基)-1-甲基哌啶-2-酰胺;甲哌卡因,10 MM DMSO 溶液 |
| 英文名稱 | N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide |
| 英文同義詞 | Polocaine;1-Methyl-2',6'-pipecoloxylidide;2',6'-Pipecoloxylidide, 1-methyl- (6CI, 8CI);2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (9CI);Carbocain;DL-Mepivacaine;Mepicaine;Scandicain |
| CAS號 | 96-88-8 |
| 分子式 | C15H22N2O |
| 分子量 | 246.35 |
| EINECS號 | 202-543-0 |
| 相關(guān)類別 | 藥物雜質(zhì)及中間體;research chemical |
| Mol文件 | 96-88-8.mol |
| 結(jié)構(gòu)式 |  |
2-甲基-2,6-壬二烯-1-胺 性質(zhì)
| 熔點(diǎn) | 150-151° |
|---|---|
| 沸點(diǎn) | 389.35°C (rough estimate) |
| 密度 | 0.9978 (rough estimate) |
| 折射率 | 1.6280 (estimate) |
| 儲存條件 | Store at -20°C |
| 溶解度 | DMF：30 mg/ml； DMSO：25 mg/ml；乙醇：30 mg/ml；乙醇:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| 形態(tài) | 結(jié)晶固體 |
| 酸度系數(shù)(pKa) | 14.85±0.70(Predicted) |
| 顏色 | 白色至米白色 |
| 水溶解性 | 2.217g/L(25 ºC) |
| EPA化學(xué)物質(zhì)信息 | 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (96-88-8) |
Mepivacaine 是一種酰胺型藥劑，可暫時(shí)使局部失去知覺。Mepivacaine 與神經(jīng)元細(xì)胞膜上特定的電壓門控鈉離子通道結(jié)合，抑制鈉離子內(nèi)流和膜去極化。
Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.
安全信息
| TSCA | TSCA listed |
|---|