• MOLECULAR FORMULA :

• C27-H46-O

• MOLECULAR WEIGHT :

• 386.73

• WISWESSER LINE NOTATION :

• L E5 B666 LUTJ A1 E1 FY1&3Y1&1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 2100 mg/kg/12W-C

• TOXIC EFFECTS :

• Peripheral Nerve and Sensation - recording from peripheral motor nerve Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 12180 mg/kg/40W-C

• TOXIC EFFECTS :

• Liver - changes in liver weight Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 800 mg/kg/43W-I

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 15 gm/kg/47W-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Implant

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 800 mg/kg

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site of application

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 60 gm/kg/2W-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• DOSE :

• 175 mg/kg

• SEX/DURATION :

• female 8-14 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• DOSE :

• 1900 mg/kg

• SEX/DURATION :

• female 1-19 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 6 gm/kg

• SEX/DURATION :

• female 1-31 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

• TYPE OF TEST :

• DNA adduct

• TEST SYSTEM :

• Rodent - mouse Cells - not otherwise specified

• DOSE/DURATION :

• 1 umol/L

• REFERENCE :

• CJBBDU Canadian Journal of Biochemistry and Cell Biology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.61- 1983- Volume(issue)/page/year: 62,94,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,99,1976 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,95,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,161,1987 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80865 No. of Facilities: 1321 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 13980 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80865 No. of Facilities: 4091 (estimated) No. of Industries: 5 No. of Occupations: 11 No. of Employees: 41411 (estimated) No. of Female Employees: 30220 (estimated)