Product Details
| Product Name: DIAZOXIDE | CAS No.: 364-98-7 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2025/09/25 |
| Lead time: In stock | Packaging: bottle/drum/bucket/IBC, as request. |
| Delivery: By sea, by air, by express | Origin: Manufacturer |
| Name: Sun |
1. Product information
| Name | diazoxide |
|---|---|
| Synonym | More Synonyms |
| Description | Diazoxide is an ATP-sensitive potassium channel activator ; can be used to treat hyperinsulinism. |
|---|---|
| Related Catalog | Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease |
| In Vitro | Diazoxide has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia[1].Diazoxide could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage[2]. |
| In Vivo | Diazoxide attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels[3]. Treatment with diazoxide in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg[4]. |
| Cell Assay | Diazoxide is dissolved in DMSO to prepare 50 mM stock solution. NSC-34 cells are allowed to differentiate for 8 weeks under reduced serum conditions and then seeded in 24-well plates. Glutamate is dissolved in culture medium and added to cultures at concentration of 10 μM for 24 h. Cell treatment with 100 μM diazoxide starts 2 h before glutamate exposure. Cell viability is measured by the MTT assay[2]. |
| Animal Admin | Rats: Adult male Sprague-Dawley rats with induced cerebral ischemia (n=10 per group) receive an intraperitoneal injection of 0.1% DMSO (1?mL; vehicle group), diazoxide (10?mg/kg; DZ group), or diazoxide (10?mg/kg) plus 5-hydroxydecanoate (5?mg/kg; DZ + 5-HD group) 30?min after CPR. The control group (sham group, n=5) undergoes sham operation, without cardiac arrest. Mitochondrial respiratory control rate (RCR) is determined. Brain cell apoptosis is assessed using TUNEL staining. Expression of Bcl-2, Bax, and protein kinase C epsilon (PKCε) in the cerebral cortex is determined by Western blotting and immunohistochemistry[3]. Mouse: Diazoxide is prepared by diluting a 100 mM stock solution in 10% polyethoxylated castor oil in PBS. In C57BL/6 wild-type and Kir6.2(?/?) mice, a 5 μL drop of 5 mM diazoxide is topically administered to one eye of each mouse while the fellow control eye received vehicle (DMSO and 10% polyethoxylated castor oil in the same proportion as the treated eye). IOP is measured daily at 1 hour, 4 hours, and 23 hours following treatment. Treatment with diazoxide and vehicle is continued daily for 14 consecutive days[4]. |
| References | [1]. Coetzee WA, et al. Multiplicity of effectors of the cardioprotective agent, diazoxide. Pharmacol Ther. 2013 Nov;140(2):167-75. [2]. Virgili N, et al. K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action viaantioxidative pathway activation. PLoS One. 2013 Sep 11;8(9):e75189. [3]. Wu H, et al. Diazoxide Attenuates Postresuscitation Brain Injury in a Rat Model of Asphyxial Cardiac Arrest by Opening Mitochondrial ATP-Sensitive Potassium Channels. Biomed Res Int. 2016;2016:1253842. [4]. Chowdhury UR, et al. ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo. Invest Ophthalmol Vis Sci. 2013 Jul 22;54(7):4892-9. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 414.8±47.0 °C at 760 mmHg |
| Melting Point | >310°C |
| Molecular Formula | C8H7ClN2O2S |
| Molecular Weight | 230.671 |
| Flash Point | 204.6±29.3 °C |
| Exact Mass | 229.991669 |
| PSA | 66.91000 |
| LogP | 1.08 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.692 |
| Storage condition | Store at RT |
| Water Solubility | 0.1 M NaOH: soluble |
diazoxide MSDS(Chinese) |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Email address : elin@fdachem.com
Mob: 86 13526505137
WhatsApp/Skype/Wechat/LINE: 86 13526505137
Company Profile Introduction
Henan Fengda Chemical Co., Ltd. a research customization and supplier specializing in PPb grade ultra-high purity electronic chemicals, deeply rooted in the semiconductor and new display fields, committed to providing the most core and purest chemical components for photoresist and high-end display materials.
We provide key monomers for KrF/ArF photoresist, photoacid generators (PAGs), photoacids, and etching solution raw materials, providing cornerstone materials for advanced process photoresist formulations;
We take ICP-MS full spectrum metal impurity analysis as the quality cornerstone and provide ICP-MS metal impurity COA reports to meet the strict industry requirements for PPb grade electronic chemical materials. The COA report contains important data such as NA, Mg, K, Ca, Al, Cr, Fe, Ni, Cu, Zn, Pb, Ag, etc. To provide customers with pure and reliable source assurance for cutting-edge research and stable production.
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