(-)-Epicatechin NEW
| Price | $48 | $61 | $78 |
| Package | 10mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: (-)-Epicatechin | CAS No.: 490-46-0 |
| Purity: 98.61% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | (-)-Epicatechin |
| Description | (-)-Epicatechin (Epicatechin) belongs to natural products and is a COX-1 inhibitor (IC50 = 3.2 μM) with cell permeability. By blocking the nuclear localization of the p65 subunit of NF-κB, this compound inhibits IL-1β-induced iNOS expression and possesses significant anti-inflammatory activity. |
| Cell Research | Panc-1 cells are seeded into T-150 flasks and on the next day, cells are treated with different concentrations of (-)-epicatechin for 1 h, then harvested and solubilized in 10 mM HEPES (pH 7.4), 40 mM KCl, 1%Tween-20, 1 μM oligomycin, 1 mM PMSF,10 mM KF, 2 mM EGTA, and 1 mM Na3VO4. COX activity is measured in the presence of 20 mM ascorbate and 200 μM substrate cytochrome c from cow heart.(Only for Reference) |
| In vitro | Methods: Panc-1, U87, and MIA PaCa-2 cancer cells as well as normal human fibroblasts were treated with (-)-epicatechin to detect mitochondrial respiration, oxygen consumption, radiation sensitivity under combined irradiation, and levels of Chk2 phosphorylation and p21 induction. Results: (-)-Epicatechin stimulated mitochondrial respiration and oxygen consumption only in Panc-1 cells; selectively enhanced radiation sensitivity in cancer cells (REF 1.7, 1.5, and 1.2 for Panc-1, U87, and MIA PaCa-2, respectively) without enhancement in normal fibroblasts (REF = 0.9); and increased Chk2 phosphorylation and p21 induction only in cancer cells when combined with irradiation.[1] |
| In vivo | Methods: 26-month-old C57BL/6 aged mice were administered (-)-epicatechin (1 mg/kg, twice daily) by gavage for 2 weeks (vehicle: water). Additionally, 6 middle-aged subjects (41 ± 5 years) were given (-)-epicatechin capsules (25 mg, twice daily) for 7 days. Muscle regulatory factors and hand grip strength were measured. Results: (-)-Epicatechin reduced elevated myostatin and β-galactosidase, and increased follistatin and Myf5 in aged mice; in humans, it increased hand grip strength (~7%) and plasma follistatin/myostatin ratio, reversing aging-related changes.[2] Methods: 5-month-old C57BL/6 male mice were randomly divided into control group, training group, detraining + placebo (water) group, and detraining + (-)-epicatechin (1 mg/kg, gavage, twice daily) group. Skeletal muscle capillary density, VEGF-A/TSP-1 expression, oxidative enzyme activity, and endurance were measured. Results: Compared with the placebo group, (-)-epicatechin significantly increased skeletal muscle capillary density and oxidative enzyme activity in detrained mice, maintained mitochondrial complex IV and cytochrome c oxidase activity, reduced the decline in VEGF-A/TSP-1 ratio, and preserved endurance comparable to the training group.[3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : 2.25 mg/mL (7.75 mM), Sonication is recommended. DMSO : 80 mg/mL (275.61 mM), Sonication is recommended. 50% PEG300+50% Saline : 5 mg/mL (17.23 mM) 0.5% CMC-Na : 5 mg/mL (17.23 mM), Sonication is recommended. |
| Keywords | Ferroptosis | Epicatechol | epi-Catechin | EndogenousMetabolite | Endogenous Metabolite | COX |
| Inhibitors Related | Sucrose | Aceglutamide | Hemin | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Guanidine thiocyanate | Malic acid | Glycerol | Thymidine | Trometamol | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Marine Natural Product Library | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Flavor Natural Product library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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