Firocoxib
| Price | $40 |
| Package | 1Kg/Bag |
| Min. Order: | 1Kg/Bag |
| Supply Ability: | 1000KG |
| Update Time: | 2021-03-19 |
Product Details
| Product Name: Firocoxib | CAS No.: 189954-96-9 |
| EC-No.: 200-001-2 | Min. Order: 1Kg/Bag |
| Purity: 99% | Supply Ability: 1000KG |
| Release date: 2021/03/19 | |
| Molecular Weight: 336.403 |
Firocoxib
| Common Name | Firocoxib | ||
|---|---|---|---|
| CAS Number | 189954-96-9 | Molecular Weight | 336.403 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 563.9±50.0 °C at 760 mmHg |
| Molecular Formula | C17H20O5S | Melting Point | 78-80°C |
| MSDS | N/A | Flash Point | 294.8±30.1 °C |
Use of Firocoxib
Firocoxib(ML 1785713) is a potent and selective cyclooxygenase (COX)-2 inhibitor with IC50 of 0.13 uM, 58 fold sensitivity for COX2 VSCOX1.IC50 value: 0.13 uM [1]Target: COX2 inhibitorin vitro: Blood concentrations resulting in 50% inhibition of COX-1 and COX-2 activity in vitro were 75 +/- 2 microM and 0.13 +/- 0.03 microM, respectively, and selectivity for inhibiting COX-2 relative to COX-1 was 58. Firocoxib had moderate to high oral bioavailability (54% to 70%), low plasma clearance (4.7 to 5.8 mL/min/kg), and an elimination half-life of 8.7 to 12.2 hours [1]. in vivo: Administration of firocoxib did not cause any adverse effects on GI, or hematological or serum biochemical variables and appears to have been well tolerated by dogs [2]. Firocoxib (0.5 mg/kg) was initially administered i.v. to calves, and following a 14-day washout period, animals received firocoxib orally prior to cautery dehorning. Firocoxib concentrations were determined by liquid chromatography-tandem mass spectrometry [3]. Firocoxib 5 mg/kg was given orally once daily for 180 days to five dogs with clinical signs and histopathological lesions consistent with solar dermatitis/actinic keratosis. On days 0, 50 and 180, the severity of erythema, skin shine, induration and the number of comedones were evaluated by a clinical scoring system [4].
Packaging and shipping
|
Packaging Detail |
0.5kgs/Al-foil bag 1.0kgs/Al-foil bag 2.0kgs/Al-foil bag 5.0 kgs/Al-foil bag 25.0 kgs/drum or upon customers' request. |
|
Storage |
Store in a well-closed container away from moisture |
|
Shelf Life |
2 years if sealed and store away from direct sun light. |
|
Delivery Detail |
within 3 days after get the payment |
|
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