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Postion:Product Catalog >API>Antineoplastic agents>Tinib Antineoplastic drugs>Sunitinib
Sunitinib
  • Sunitinib

Sunitinib

Price $160
Package 20g/Bag
Min. Order: 20g
Supply Ability: 100KG
Update Time: 2021-11-02

Product Details

Product Name: Sunitinib CAS No.: 557795-19-4
Min. Order: 20g Purity: 99%
Supply Ability: 100KG Release date: 2021/11/02

Product Name: Sunitinib

CAS: 557795-19-4

MF: C22H27FN4O2

MW: 398.47

Description

Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC50 values in the 4–14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC50s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer.




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