Clomastine fumarate is a potent, long-acting, quick acting, highly selective histamine H1 receptor antagonist, which can block H1 receptor and antagonize cytotoxicity. It is mainly used in allergic skin diseases, allergic rhinitis and other allergic diseases, bringing good news to patients suffering from allergic diseases all the year round“ Statins are potent, long-acting and highly selective histamine H1 receptor blockers, which have no inhibitory effect on cholinergic activity of central nervous system, sedation and drowsiness. They are mostly used in allergic rhinitis, anti allergic asthma, urticaria, eczema, dermatitis and skin pruritus. In recent years, more and more attention has been paid to the local administration of statins. Nasal and ophthalmic drugs have been developed and become a kind of non hormonal drugs in the treatment of allergic rhinitis.