Product Details
| Product Name: Chlorpheniramine maleate | CAS No.: 113-92-8 |
| EC-No.: 204-037-5 | Min. Order: 1Kg/Bag |
| Purity: 99% | Supply Ability: 2500kg/month |
| Release date: 2024/09/18 | |
| Appearance: White powder |
| Product Name: | Chlorpheniramine maleate | ||
| Synonyms: | 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate;1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat;2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1); allerclor; allergin; alunex; antagonate; carbinoxamidemaleate | ||
| CAS: | 113-92-8 | ||
| MF: | C20H23ClN2O4 | ||
| MW: | 390.86 | ||
| EINECS: | 205-054-0 | ||
| Product Categories: | Intermediates & Fine Chemicals; Pharmaceuticals; Antagonists; Histaminergics;Neurotransmitters;TELDRIN;API | ||
| Melting point | 130-135 °C(lit.) | ||
Chlorpheniramine maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an is chemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate.
Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.
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