Chloro-di(propan-2-yl)silicon CAS NO.2227-29-4

·  Silylates and reduces β-hydroxy ketones selectively

·  Reduces β-hydroxyketones stereoselectively

·  Used in a silylation-reduction-allylation sequence of β-hydroxy esters to homoallylic-substituted 1,3-diols

·  Used in the silylation-hydrosilation-oxidation of allyl alcohols to 1,3-diols

·  Reaction carried out in diastereoselective manner

·  Photochemically removable

·  Reduces β-hydroxy ketones to anti-1,3 diols

·  Used in the tethered reactions of unsaturated alcohols

·  Used in the silicon-based cross-coupling of vinyl ethers with aryl iodides

BOILING POINT: 137°

MOLECULAR WEIGHT: 150.72

SPECIFIC GRAVITY: 0.872

FLASHPOINT: 22°C (72°F)

HMIS KEY: 3-4-1-X

HYDROLYTIC SENSITIVITY: 8: REACTS RAPIDLY WITH MOISTURE, WATER, PROTIC SOLVENTS

FORMULA: C6H15CLSI

REFRACTIVE INDEX: 1.4278

TSCA: TSCA

APPLICATION: REVIEW OF SYNTHETIC UTILITY.1
REDUCES ?-HYDROXYKETONES STEREOSELECTIVELY.2
USED IN THE TETHERED REACTIONS OF UNSATURATED ALCOHOLS.3
USED IN THE SILICON-BASED CROSS-COUPLING OF VINYL ETHERS WITH ARYL IODIDES.4

REFERENCE: 1. HANDBOOK OF REAGENTS FOR ORGANIC SYNTHESIS, REAGENTS FOR SILICON-MEDIATED ORGANIC SYNTHESIS, FUCHS, P. L. ED., JOHN WILEY AND SONS, LTD., 2011, P. 151-156.
2. ANWAR, S. ET AL. CHEM. COMM. 1986, 831.
3. ROBERTSON, J. ET AL. TETRAHEDRON LETT. 1998, 39, 669.
4. EVANS, P. A.; BAUM, E. W. J. AM. CHEM. SOC. 2004, 126, 11150.

Daken Chemical Limited  is a hi-tech company specialized in the area of R&D, production and sale of high end organosilicone productions. We have a group of scientific researchers with rich experience in this area. Daken concentrates on the exploit and manufacturing of kinds of new organosilicone monomers and intermediates. Our products cover organohalosilanes, organic amino silanes, organic hydrogen silanes, organoalkoxysilanes, chain-alkyl silanes, alkynylsilanes and fluoroalkyl silane, ect.

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