Product Details
| Product Name: Irinotecan | CAS No.: 97682-44-5 |
| EC-No.: 691-567-9 | Min. Order: 1KG |
| Purity: 99.9% | Supply Ability: 500MT/month |
| Release date: 2023/03/27 |
99% Bulk Irinotecan Hydrochloride Anticancer Irinotecan Powder
| Name | Irinotecan |
| CAS No. | 97682-44-5 |
| EINECS | N/A |
| MF | C33H39ClN4O6 |
| MW | 623.14 |
| Storage temp. | 2-8°C |
| Purity | 99% min |
| Usage | Antineoplastic agents; API |
| Appearance | Light Yellow Powder |
Irinotecan is a semi-synthetic derivatives of camptothecin which can be specifically combined with the topoisomerase I. Topoisomerase I induced reversible single-strand breaks, so that double-stranded structure of DNA unwinded. Irinotecan and its active metabolite SN-38 with topoisomerase I-DNA complex binding, thereby preventing the fractured single-stranded nucleic acid to be connected. Existing research suggests that irinotecan cytotoxicity due to DNA synthesis process. Replicase and a topoisomerase I-DNA irinotecan (or SN-38) triple complex interactions, causing DNA double-strand breaks. Mammalian cells can not efficiently repair the DNA double-strand breaks.


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- Since: 2018-04-16
- Address: Guangzong Economic Development Zone, Xingtai City, Hebei Province
+86-17731987558
xingjiu@xingjiubiotech.com

China