2-chlorpyrazine has a resonant body, and its molecules are planar. Pauling, a scientist, proposed that the standard heat of 2-chlorpyrazine is 40K cal/mol, which is as stable as benzene ring and pyrimidine, but the resonance energy obtained by different methods varies greatly. 2-chlorpyrazine is a very weak base. Its aromatics are similar to pyridine, it is very unlikely to undergo electrophilic substitution reactions, and it is more active to nucleophiles. When the hydrogen on the carbon atom of its molecule is replaced by a methyl group or halogen, the hydrogen on the halogen or methyl group is active.

Appication:

2-chlorpyrazine is an important new heterocyclic organic intermediate, but there is no real industrial plant to produce it in China. In addition, it is also an important industrial raw material, widely used in medicine, pesticides, dyes and other industries. Pyrazine ring is a hot field in pharmaceutical research because of its biological activity and irreplaceable role of other groups or functional groups in the synthesis of drugs. In addition, 2-chlorpyrazine has special chemical properties and medicinal activity, and is an intermediate of many medicines and pesticides, and its application prospect is very broad.