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Postion:Product Catalog >2',5'-Dideoxyadenosine
2',5'-Dideoxyadenosine
  • 2',5'-Dideoxyadenosine

2',5'-Dideoxyadenosine NEW

Price $33 $76 $122
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2025-04-28

Product Details

Product Name: 2',5'-Dideoxyadenosine CAS No.: 6698-26-6
Purity: 99.55% Supply Ability: 10g
Release date: 2025/04/28

Product Introduction

Bioactivity

Name2',5'-Dideoxyadenosine
Description2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM.
Cell ResearchPrimary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3]
Animal ResearchMale Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3]
In vitro2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].
In vivo2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) completely inhibits the natriuretic, diuretic, and K+ and Cl- sparing effects of Fr-EtOAc in rats [4].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 2.35 mg/mL (9.99 mM), Sonication is recommended.
KeywordsP-site | nucleoside | Inhibitor | inhibit | heart | cyclase | Beta Receptor | antiadrenergic | analog | AdrenergicReceptor | Adrenergic Receptor | Adenylylcyclase | Adenylyl cyclase (AC) | Adenylyl cyclase | adenylyl | Adenylate Cyclase | 2',5'-Dideoxyadenosine | 2',5'Dideoxyadenosine | 2',5' Dideoxyadenosine
Inhibitors RelatedAdiphenine hydrochloride | Nanofin | Clozapine N-Oxide | Pilocarpine nitrate | Urethane | Ribavirin | Octopamine hydrochloride | D-Menthol | Choline chloride | Propoxur | Trazodone hydrochloride | Mianserin hydrochloride
Related Compound LibrariesAnti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Adrenergic Receptor-Targeted Compound Library | GPCR Compound Library | Human Metabolite Library | Nucleotide Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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