Product Details
| Product Name: Ibrutinib | CAS No.: 936563-96-1 |
| Min. Order: 10G | Purity: 99.5% |
| Supply Ability: 10MT | Release date: 2019/01/15 |
| Appearance: White to whitish crystal powder | MF : C25H24N6O2 |
| Application: Waldenstrom's macroglobulinemia. |
Ibrutinib (Imbruvica) is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK), that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia, a form of non-Hodgkin's lymphoma.
Quick View:
| Product Name | Ibrutinib |
| CAS | 936563-96-1 |
| Appearance | White Crystalline Powder |
| MF | C25H24N6O2 |
| MW | 440.5 |
| Purity | 99%min |
| Application | 1.Mantle cell lymphoma (MCL) who have received at least one prior therapy. 2.Chronic lymphocytic leukemia (CLL) who have received at least one prior therapy. 3.Waldenstrom's macroglobulinemia. |
Descriptions:
Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease.
COA:
| Items | Specifications | Results |
| Appearance | White to whitish crystal powder | Conforms |
| Loss on drying | NMT 0.5% | 0.33% |
| Residue on ignition | NMT 0.1% | Conforms |
| Heavy metal | NMT 20ppm | Conforms |
| Assay (HPLC) | NLT 99.5% | 99.77% |
| Related substances | NMT 0.5% | 0.23% |
| Single impurity | NMT 0.1% | 0.07% |
| Conclusion | Complies to the Enterprise standard. | |
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
2 . Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
3 . Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate
4 . Warm after-sale service Any of your question would be solved for the first as soon as possible.
Ibrutinib 936563-96-1 Pharmaceutical Intermediate
Ibrutinib 936563-96-1 Raw Chemical Product
Ibrutinib 936563-96-1 Supplier & manufactuer
Company Profile Introduction
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