3M-011 NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: 3M-011 | CAS No.: 642473-62-9 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | 3M-011 |
| Description | 3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3]. |
| In vitro | 3M-011 (0-100 μg/mL; 24 hours; B16-F10 melanoma cells) treatment decreases B16-F10 melanoma cell counts[1]. In humans, 3M-011 activates TLR7 and TLR8, whereas in mice, it activates only TLR7[1]. NF-κB reporter is integrated into HEK-293 cells transfected with human or mouse TLR7 or TLR8, resulting in dose-dependent NF-κB-controlled luciferase activity, except with mouse TLR8. 3M-011 enhances natural killer (NK) cell cytotoxicity[1]. |
| In vivo | The treatment of scid/NOD mice bearing B16-F10 cells with 3M-011 (1 mg/kg; intravenous injection; every other day for six doses; female scid/NOD mice) demonstrates antitumor effects and induces a dose-dependent increase in serum concentrations of TNF-α and IFN-α/β. Additionally, wild-type C57BL/6 mice are subcutaneously injected with varying doses of 3M-011 (0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, or 10 mg/kg)[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | TLR8 | TLR7 | H3N2 influenza viral | 3M-011 | 3M011 | 3M 011 |
| Inhibitors Related | Polyinosinic-polycytidylic acid sodium | CU-CPD107 | Hydroxychloroquine | Chloroquine phosphate | Hydroxychloroquine sulfate | RV01 | Chloranil | Chloroquine | CU-115 | Imiquimod | TLR3-IN-1 | Resiquimod |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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