4-DAMP NEW
| Price | $111 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: 4-DAMP | CAS No.: 1952-15-4 |
| Supply Ability: 10g | Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | 4-DAMP |
| Description | 4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease. |
| In vitro | 4-DAMP apparent affinities (pKB) at the muscarinic M3 receptor was 8.8, pKi=9.3. 4-DAMP apparent affinities (pKB) at the muscarinic M5 receptor was 8.6, pKi=8.9 . [1] |
| In vivo | An AR model was established by inducing male guinea pigs (4-6 weeks of age) with ovalbumin. 4-DAMP group animals were treated with ipratropium bromide (0.6 mg/kg) and 4-DAMP (0.12 or 0.6 mg/kg) by intranasal instillation per nostril daily.??The AR symptom scores and nasal secretion weights of animals treated with 4-DAMP were reduced significantly, goblet cell metaplasia was reversed, and eosinophil infiltration was visibly alleviated.?[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (177.25 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (11.08 mM), Sonication is recommended. |
| Keywords | M3 mAChR | 4-DAMP | 4DAMP | 4 DAMP |
| Inhibitors Related | Kaolin | Stavudine | Aceglutamide | Urea | D(+)-Raffinose pentahydrate | Metronidazole | Hydroxypropyl Cellulose | Doxycycline | Formamide | N,N-Dicyclohexylcarbodiimide | Gluconate Calcium | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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