4-P-PDOT NEW
| Price | $52 | $89 | $186 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: 4-P-PDOT | CAS No.: 134865-74-0 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | 4-P-PDOT |
| Description | 4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. |
| In vitro | In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. However, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86[1]. |
| In vivo | 4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice[2]. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 41.67 mg/mL (149.15 mM), Sonication is recommended. |
| Keywords | oxidative | Nrf2 | MTReceptor | MT2 receptor | MT2 | MT Receptor | memory | MelatoninReceptor | Melatonin Receptor | Melatonin | Inhibitor | inhibit | GSSG | GSH | ERK | damage | 4-P-PDOT | 4PPDOT | 4 P PDOT |
| Inhibitors Related | Agomelatine | Ramelteon | ACH-000143 | glycine | Methyl Linolenate | 6-Chloromelatonin | Tasimelteon | Agomelatine (L(+)-Tartaric acid) | UCM 608 | Melatonin | Piromelatine | Luzindole |
| Related Compound Libraries | Histamine & Melatonin Receptor-Targeted Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Antioxidant Compound Library | Multi-Target Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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