Product Details
| Product Name: AZD6482 (S-isomer) | CAS No.: 1173900-37-2 |
| Min. Order: 10KG | Purity: 99 |
| Supply Ability: 100kg | Release date: 2019/01/15 |
Chemical Information
| Product Name | AZD6482 (S-isomer) |
|---|---|
| Iupac Chemical Name | (S)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid |
| Synonyms | AZD6482 (S); AZD6482; AZD-6482; AZD 6482 |
| Molecular Formula | C22H24N4O4 |
| Molecular Weight | 408.458 |
| Smile | CC=1C=C(C=2N(C(C=C(N2)N2CCOCC2)=O)C1)[C@H](C)NC1=C(C(=O)O)C=CC=C1 |
| InChiKey | IRTDIKMSKMREGO-HNNXBMFYSA-N |
| InChi | InChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m0/s1 |
| Cas | 1173900-37-2 |
Technical Data
Description
AZD6482 is a potent, selective and ATP competitive PI3K inhibitor (IC(50) 0.01 μm). AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). This is the first human target validation for PI3K inhibition as anti-platelet therapy showing a mild and generalized antiplatelet effect attenuating but not completely inhibiting multiple signaling pathways with an impressive separation towards primary hemostasis. AZD6482 at 'supratherapeutic' plasma concentrations may attenuate insulin signaling, most likely through PI3K inhibition.
Company Profile Introduction
Hubei XinRunde Chemical Co., Ltd covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Products sell well all over the country and exported to Europe and the United States and Southeast Asia,and so on.
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