Probucol
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Probucol | CAS No.: 23288-49-5 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| Probucol Basic information |
| Description References |
| Product Name: | Probucol |
| Synonyms: | PROBUCOL;4,4’-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl)-pheno;biphenabid;bisbid;bisphenabid;dh581;4,4'-ISOPROPYLIDINEDITHIO-BIS-(2,6-DI-TERT-BUTYL)PHENOL;4-({1-[(4-hydroxy-3,5-di-t-butylphenyl)thio]-1-methylethyl}thio)-2,6-di-t-butylphenol |
| CAS: | 23288-49-5 |
| MF: | C31H48O2S2 |
| MW: | 516.84 |
| EINECS: | 245-560-9 |
| Product Categories: | Cardiovascular;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API;LORELCO;Isolabel;Cardiovascular APIs |
| Mol File: | 23288-49-5.mol |
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| Probucol Chemical Properties |
| Melting point | 126-128°C |
| Boiling point | 571.58°C (rough estimate) |
| density | 1.0008 (rough estimate) |
| refractive index | 1.5341 (estimate) |
| storage temp. | Desiccate at +4°C |
| Merck | 14,7755 |
| CAS DataBase Reference | 23288-49-5(CAS DataBase Reference) |
| Safety Information |
| RTECS | AL3705000 |
| Probucol Usage And Synthesis |
| Description | Probucol is a kind of bis-phenol antioxidant with anti-hyperlipidemic activity. It had been initially developed for the treatment of coronary artery disease. However, its clinical trials were stopped after people found that it could lower the HDL and LDL cholesterol in patients of a history of heart disease. Probucol exerts its effect through accelerating the fractional rate of low-density (LDL) catabolism which is in the final pathway of cholesterol elimination inside the body. It may also inhibit the early stage of cholesterol biosynthesis and dietary cholesterol absorption. |
| Chemical Properties | White Solid |
| Uses | antihyperlipidemic |
| Uses | Probucol is an antilipemic. |
| Uses | anti-hyperlipoproteinemic |
| Uses | An antioxidant, anti-inflammatory, and hypocholesterolemic agent which inhibits atherogenesis in murine models. |
| Definition | ChEBI: A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high l vels of cholesterol in blood. |
| Biological Activity | Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com