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Postion:Product Catalog >Chemical Reagents>Organic reagents>Esters>Butyl Ester compounds>Butylparaben
Butylparaben
  • Butylparaben

Butylparaben

Price $1
Package 1KG
Min. Order: 1G
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: Butylparaben CAS No.: 94-26-8
Min. Order: 1G Purity: 98%
Supply Ability: 100KG Release date: 2019/07/06

AD68

Product Name: Butylparaben
Synonyms: 4-hydroxy-benzoicacibutylester;4-Hydroxybenzoicaicdbutylester;Aseptoform Butyl;aseptoformbutyl;Benzoic acid, 4-hydroxy-, butyl ester;Benzoic acid, p-hydroxy-, butyl ester;Benzoicacid,4-hydroxy-,butylester;Butyl Butex
CAS: 94-26-8
MF: C11H14O3
MW: 194.23
EINECS: 202-318-7
Product Categories: Pharmaceutical Raw Materials;Aromatics;API
Mol File: 94-26-8.mol
Article illustration
 
Butylparaben Chemical Properties
Melting point  67-70 °C(lit.)
Boiling point  156-157 °C3.5 mm Hg(lit.)
density  1.28
FEMA  2203 | BUTYL P-HYDROXY BENZOATE
refractive index  1.5115 (estimate)
Fp  181℃
storage temp.  0-6°C
solubility  Soluble in DMSO, ethyl acetate, methanol.
form  Crystalline Powder
color  White to almost white
Water Solubility  <0.1 g/100 mL at 17 ºC
Merck  14,1584
BRN  1103741
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong alkalies.
CAS DataBase Reference 94-26-8(CAS DataBase Reference)
NIST Chemistry Reference P-hydroxybenzoic acid, n-butyl ester(94-26-8)
EPA Substance Registry System Benzoic acid, 4-hydroxy-, butyl ester(94-26-8)
 
Safety Information
Risk Statements  36/37/38
Safety Statements  22-24/25-37/39-26
WGK Germany  2
RTECS  DH1980000
TSCA  Yes
Hazardous Substances Data 94-26-8(Hazardous Substances Data)
Butylparaben Usage And Synthesis
Chemical properties It appears as white crystal powder, having slightly special odor. It is slightly soluble in water, being soluble in alcohol, ether and chloroform.
Production method It is derived from the esterification between p-hydroxybenzoic acid and butanol. Butanol and p-hydroxybenzoic acid are heated together for being dissolved, slowly added dropwise of sulfuric acid, continue the refluxing for 8h. After cooling, add 4% sodium carbonate solution, separate the water layer, steam out the butanol, let it cool, filter to obtain the crude product, and then carry out ethanol recrystallization (solubility in ethanol: 200g/100ml).
Take sulfuric acid as a catalyst; derive it from the reaction between p-hydroxybenzoic acid and butanol.
Uses 1. Butylparaben can be used for the antibacterial and anticorrosion of drugs, cosmetics and food.
2. As a kind of preservative; Because of the low solubility in water, Butylparaben is usually prepared into ethanol solution, acetic acid solution or sodium hydroxide solution. To improve the solubility, several different esters are often used. For example, three parts of isobutyl, four parts of isopropyl and three parts of butyl are formulated as a co-soluble mixture and the mixture is used as an oil-in-water emulsifier. This preparation is easy to use in soy sauce and other foods, the solubility of butyl ester alone can be increased by 2 to 3 times. For soy sauce, 5% sodium hydroxide solution can be added to the goods of 20% to 25%, and then slowly added to the sauce having been heated to about 80 ℃. Acetic acid solution or ester type emulsifier can also be used. The usage amount of anti-mold soy sauce is 0.05~0.10g/L. Vinegar can be used in acetic acid or sodium hydroxide solution. Soft drinks can be used in the solution of sodium hydroxide, but usually used in combination with benzoic acid and dehydroacetic acid.
3. Used as organic synthesis intermediates; the anti-corrosion additives of medicine, food, cosmetics, film and high-grade products; reagents. Being used as germicide preservative of food is Butylparaben's major application. In the p-hydroxybenzoic acid esters, it can give the strongest anti-corrosion bactericidal effect. Because of its poor water solubility, it is often used with other esters in combination.
4. For preservatives and disinfectants
Toxicity ADI is subject to postponed decision (FAO/WHO, 2001).
LD50: 16.0 g/kg (mouse, subcutaneous injection).
Mice subjecting to short-term toxicity test have gotten inhibited weight increase. There have been reports regarding to the acute dermatitis for human beings. In the p-hydroxybenzoic acid esters, this product gives the best anti-corrosion effect, but also the largest toxicity.
Content analysis 2g (accurate to 0.1mg) was taken and dried in silica gel for 5h before being transferred to the flask. Add 40 mL of 1mol/L of sodium hydroxide, flush flasks with water. Cover the surface of the dish and apply a small fire to boil 1h before cooling. Add 5 drops of bromothymol blue solution (TS-56), titrate the excess sodium hydroxide with 1 mol/L sulfuric acid, and make the color of the solution consistent with the buffer containing the same indicator (pH 6.5). Carry out a blank test at the same time and make the necessary calibration. 1ml/L sodium hydroxide per milliliter corresponds to the 194.2 mg of this product (C11H14O3).
Usage limit Japan (1998, calculated on p-hydroxybenzoic acid; the data in parentheses is the amount converted into equivalent amount of this product, g/ kg), soy sauce 0.25 g/L (0.35 g/L), vinegar 0.1 g/L (0.14 g/L); Soft drinks and syrup: 0.1 (0.14); fruit sauce: 0.2 (0.28); fruits and vegetables 0.012 (0.016).
Hazards & Safety Information Category :Toxic substances
Toxic classification: poisoning
Acute toxicity:  Oral-mouse LD50: 13200 mg/kg; celiac-mouse LD50: 230 mg/kg
Stimulation Data:  Skin-Guinea Pig 5%/48 hours Mild
Flammability and Hazardous characteristics:  Thermal decomposition; pungent irritation Smoke
Storage and transportation characteristics:  Treasury: ventilated, low temperature and dry
Fire extinguishing agent:  water, dry powder, foam, carbon dioxide
Chemical Properties white crystalline powder
Uses An antimicrobial
Uses antifungal, preservative
General Description Odorless white crystals or crystalline powder. Tasteless, but numbs the tongue. Aqueous solutions slightly acidic to litmus.
Air & Water Reactions Insoluble in water.
Reactivity Profile Butylparaben is incompatible with strong oxidizing agents and strong caustics.
Fire Hazard Flash point data for Butylparaben are not available; however, Butylparaben is probably combustible.
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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