Lonidamine
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Lonidamine | CAS No.: 50264-69-2 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| Lonidamine Basic information |
| Description References |
| Product Name: | Lonidamine |
| Synonyms: | af1890;dica;doridamina;DICLONDAZOLIC ACID;LONIDAMINE;1-[2,4-DICHLOROBENZYL]-1H-INDAZOLE-3-CARBOXYLIC ACID;1-[(2,4-DICHLOROPHENYL)METHYL]-1H-INDAZOLE-3-CARBOXYLIC ACID;1-(2,4-Dichlorobenzyl)indazole-3-carboxylic acid |
| CAS: | 50264-69-2 |
| MF: | C15H10Cl2N2O2 |
| MW: | 321.16 |
| EINECS: | 256-510-0 |
| Product Categories: | API;DORIDAMINA;inhibitor;Anti-cancer&immunity |
| Mol File: | 50264-69-2.mol |
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| Lonidamine Chemical Properties |
| Melting point | 207-209°C |
| density | 1.4835 (rough estimate) |
| refractive index | 1.6070 (estimate) |
| storage temp. | Store at RT |
| CAS DataBase Reference | 50264-69-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 60-22-40 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | NK7886000 |
| Toxicity | LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood) |
| Lonidamine Usage And Synthesis |
| Description | Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH). |
| References | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1477623/ https://en.wikipedia.org/wiki/Lonidamine |
| Uses | contraceptive, spermicidal |
| Definition | ChEBI: A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively. |
| Biological Activity | Anticancer and antispermatogenic agent in vitro and in vivo . Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl - channels in vitro . |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com