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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Apoptosis>Caspase inhibitors>Z-VAD-FMK
Z-VAD-FMK
  • Z-VAD-FMK

Z-VAD-FMK

Price $1
Package 1KG
Min. Order: 1G
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: Z-VAD-FMK CAS No.: 187389-52-2
Min. Order: 1G Purity: 98%
Supply Ability: 100KG Release date: 2019/07/06

AD68

Z-VAD-FMK Basic information
Product Name: Z-VAD-FMK
Synonyms: Z-VADC(OME)-FMK;methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-phenylmethoxycarbonylamino-butanoyl]amino]propanoyl]amino]-4-oxo-pentanoate;N-BENZYLOXYCARBONYL-VAL-ALA-ASP FLUOROMETHYL KETONE;Z-VAD-FLUOROMETHYLKETONE;Z-VAD-FMK;Z-VAD-FMK, METHYL ESTER;Z-VAD(OME)-FLUOROMETHYLKETONE;Z-VAD(OME)-FMK
CAS: 187389-52-2
MF: C21H28FN3O7
MW: 453.46
EINECS:  
Product Categories: Caspases/Apoptosis;Caspase/Related Products;Apoptosis;peptides;API;Inhibitors
Mol File: Mol File
Article illustration
 
Z-VAD-FMK Chemical Properties
density  1.214±0.06 g/cm3 (20 ºC 760 Torr)
Fp  396.7℃
storage temp.  −20°C
solubility  DMSO: 20 mg/mL
form  powder
color  white
InChIKey MIFGOLAMNLSLGH-QOKNQOGYSA-N
 
Safety Information
Safety Statements  22-24/25
WGK Germany  3
MSDS Information
Provider Language
SigmaAldrich English
 
Z-VAD-FMK Usage And Synthesis
Uses Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]
Biological Activity Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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  • Address: Zhengzhou High tech Zone, Henan Province, China
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