(4E)-SUN9221 NEW
| Price | $700 | $1800 |
| Package | 1mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: (4E)-SUN9221 | CAS No.: 222318-55-0 |
| Purity: 97.79% | Supply Ability: 10g |
| Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | (4E)-SUN9221 |
| Description | (4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats. |
| In vitro | In human platelet-rich plasma (PRP), (4E)-SUN9221 potently inhibits collagen-, ADP-, and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, and 14 nM, respectively. Additionally, (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1]. |
| In vivo | In conscious spontaneously hypertensive rats (SHR), (4E)-SUN9221 reduces blood pressure in a dose-dependent manner when administered orally at doses of 1, 3, and 10 mg/kg. Specifically, (4E)-SUN9221 at a dose of 3 mg/kg exhibits antihypertensive activity in SHR[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | α1A-adrenergic receptor | SUN-9221 | SUN9221 | SUN 9221 | AdrenergicReceptor | Adrenergic Receptor | 5HTReceptor | 5-HT2 | 5HT Receptor | (4E)-SUN-9221 | (4E)SUN9221 | (4E) SUN9221 |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | Octopamine hydrochloride | 1,8-Cineole | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Endocrinology-Hormone Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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