Product Details
| Product Name:
4E2RCat |
CAS No.:
432499-63-3 |
| Purity:
98.44% |
Supply Ability:
10g |
| Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | 4E2RCat |
| Description | 4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and effectively blocks coronavirus replication, as evidenced by reduced viral protein expression and decreased production of infectious virus. |
| In vitro | 4E2RCat disrupts the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), thereby inhibiting cap-dependent translation. This action significantly reduces replication of human coronavirus 229E (HCoV-229E), decreasing both the proportion of infected cells and the levels of infectious virus both inside and outside cells. The inhibition of cap-dependent translation by 4E2RCat occurs in a dose-dependent manner, specifically targeting cap-dependent FF translation without affecting EMCV IRES-driven Ren translation. Additionally, 4E2RCat curtails coronavirus replication reliant on dose and duration[1]. |
| In vivo | 4E2RCat impedes protein synthesis in vivo, and this effect is not due to elevated cell death[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 15.5 mg/mL (34 mM), Sonication and heating are recommended.
|
| Keywords | Virus Protease | Inhibitor | inhibit | Eukaryotic Initiation Factor (eIF) | eIF4E-Eif4g | Autophagy | 4E-2RCat | 4E2RCat |
| Inhibitors Related | Stavudine | Aceglutamide | Adenosine | Hemin | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Paeonol | Thymidine | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Endoplasmic Reticulum Stress Compound Library | Kinase Inhibitor Library | Anti-Viral Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | PPI Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$50.00
|
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-07-27 |
|
|
|
VIP2Y
|
Shaanxi Dideu New Materials Co. Ltd
|
2026-06-30 |
United States