5-A-RU NEW
| Price | Get Latest Price |
| Package | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2025-06-21 |
Product Details
| Product Name: 5-A-RU | CAS No.: 17014-74-3 |
| Supply Ability: 10g | Release date: 2025/06/21 |
Product Introduction
Bioactivity
| Name | 5-A-RU |
| Description | 5-A-RU (5-Amino-6-(D-ribitylamino)uracil) is an early intermediate in riboflavin biosynthesis and is found in a variety of bacteria and yeast as well as plants. 5-A-RU is also a mucosal-associated invariant T (MAIT) cell activator that forms potent MAIT-activating antigens through non-enzymatic reactions with small molecules from other metabolic pathways. |
| In vitro | METHODS: 5-A-RU plus DHA, 5-A-RU, 5-A-RU plus MeG, or 5-A-RU (0-3000μM) was used to treat mouse MAIT cells from STg (iVα19) and DTg (iVα19Vβ6) animals, and the activation of mouse MAIT cells was measured. RESULTS 5-A-RU plus MeG achieved the greatest MAIT cell activation; 5-A-RU alone also activated MAIT cells; 5-A-RU can also react with Glyx and MeG to produce pyrimidine adducts, activating mouse MAIT cells. [2] |
| In vivo | METHODS: 5-A-RU (100 nM, intraperitoneal injection) was administered to Vβ6-Tg mice and iVα19-Tg mice, and MAIT cell activation was measured. RESULTS MAIT cells were activated when 5-A-RU and MeG were mixed extemporaneously before in vivo injection, whereas 5-A-RU alone was unable to activate MAIT cells in mice. [2] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice./Shipping at ambient temperature. |
| Keywords | 5-A-RU | 5ARU | 5 A RU |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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CAS:17014-74-3
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