Product Details
| Product Name:
5-OP-RU |
CAS No.:
2408493-91-2 |
| Purity:
94.66% |
Supply Ability:
10g |
| Release date:
2026/05/15 |
Product Introduction
Bioactivity
| Name | 5-OP-RU |
| Description | 5-OP-RU belongs to immunomodulators and is an MR1-dependent MAIT cell agonist with the characteristic of efficiently activating and enriching mucosal-associated invariant T (MAIT) cells. This compound can be used as a mucosal adjuvant in research on Mycobacterium tuberculosis infection. |
| In vitro | Methods: Cynomolgus monkey and human PBMCs were stimulated with 10 nM 5-OP-RU for 6 days (proliferation assay); or BAL/blood cells were stimulated with 50 nM 5-OP-RU for 6 hours (functional assay).
Results: Cynomolgus monkey MAIT cells effectively proliferated and produced cytokines in vitro, indicating that 5-OP-RU is active in vitro, but in vivo administration led to their functional impairment. [1] |
| In vivo | Methods: To evaluate the mucosal adjuvant potential of 5-OP-RU, C57BL/6J mice were intranasally inoculated with live Vibrio cholerae or OSP:BSA conjugate vaccine, concurrently administered with 5-A-RU/MGO (5-OP-RU precursor).
Results: 5-OP-RU treatment induced significant expansion of lung MAIT cells in mice (2.6% of CD3+ cells), but only modestly enhanced mucosal OSP-IgG antibodies when combined with OSP:BSA, with no significant effect on antibody responses to live bacterial vaccine. [2] |
| Storage | Keep away from direct sunlight,Keep away from moisture,Store at low temperature
Powder: -20°C for 3 years
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (302.76 mM), Sonication is recommended. (H2O can inactivate 5-OP-RU's activity)
|
| Keywords | 5OPRU |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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