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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Neuronal Signaling>Histamine Receptor Antagonists>Lafutidine
Lafutidine
  • Lafutidine

Lafutidine

Price $1
Package 1kg
Min. Order: 1g
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: Lafutidine CAS No.: 118288-08-7
Min. Order: 1g Purity: 99%
Supply Ability: 100KG Release date: 2019/07/06
PRODUCT:: AD68
Lafutidine Basic information
Description References
Product Name: Lafutidine
Synonyms: n-(4-(4-piperidinylmethyl)pyridyl-2-oxy)butenyl-2-(furfurylsulfinyl)acetamide;LAFUTIDINE;(+-)-2-(furfurylsulfinyl)-n-(4-(4-(piperidinomethyl)-2-pyridyl)oxy-(z)-2-but;(z)-inyl)oxy)-2-butenyl);acetamide,2-((2-furanylmethyl)sulfinyl)-n-(4-((4-(1-piperidinylmethyl)-2-pyrid;enyl)acetamide;frg-8813;LAFUTIDINE(SUBJECTTOPATENTFREE)
CAS: 118288-08-7
MF: C22H29N3O4S
MW: 431.55
EINECS: 1312995-182-4
Product Categories: Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Other APIs
Mol File: 118288-08-7.mol
Article illustration
 
Lafutidine Chemical Properties
Melting point  92.7-94.9°
CAS DataBase Reference 118288-08-7(CAS DataBase Reference)
 
Safety Information
Safety Statements  24/25
HS Code  29349990
MSDS Information
 
 
Lafutidine Usage And Synthesis
Description Lafutidine is a second generation of H2-receptor antagonist. H2-receptor antagonist can strongly inhibit gastric acid secretion compared with conventional drugs such as antacids. Unlike conventional H2-receptor antagonist, lafutidine inhibits gastric acid secretion during daytime as well as nighttime in clinical studies in humans. Lafutidine also has gastroprotective activity independent of its acid antisecretory efficacy, preventing noxious agent-induced gastric mucosal injury and accelerating the repair process following gastric mucosal damage. It also protects experimentally induced reflux esophagitis, indomethacin-induced intestinal, and dextran sulfate sodium-induced colonic inflammation.
Lafutidine is used for gastric and duodenal ulcers. It is also confirmed that lafutidine can be used as an empiric treatment and superior efficacy for primary care practice patients with dyspepsia.
References [1] Tomohiko Shimatani, Masaki Inoue, Tomoko Kuroiwa, Jing Xu, Masuo Nakamura, Susumu Tazuma, Kazuro Ikawa, Norifumi Morikawa (2006) Lafutidine, a Newly Developed Antiulcer Drug, Elevates Postprandial Intragastric pH and Increases Plasma Calcitonin Gene-Related Peptide and Somatostatin Concentrations in Humans: Comparisons with Famotidine, Digestive Diseases and Sciences, 51, 114-120
[2] Bhupesh Dewan, Nisha Philipose (2011) Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial, Gastroenterology Research and Practice, 2011, Article ID 640685
[3] https://www.drugs.com
Uses Second generation histamine H2-receptor antagonist. Antiulcerative
Uses Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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  • Since: 2014-12-17
  • Address: Zhengzhou High tech Zone, Henan Province, China
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