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Postion:Product Catalog >Biochemical Engineering>Inhibitors>protein tyrosine kinase>Momelotinib
Momelotinib
  • Momelotinib
  • Momelotinib

Momelotinib

Price $2
Package 1kg
Min. Order: 1kg
Supply Ability: 100kg
Update Time: 2019-07-06

Product Details

Product Name: Momelotinib CAS No.: 1056634-68-4
Min. Order: 1kg Purity: 99%
Supply Ability: 100kg Release date: 2019/07/06
Product NUmber: : WM.562
Momelotinib Basic information
Description In vitro In vivo
Product Name: Momelotinib
Synonyms: momelotinib(JAK inhibitor)ORPHAN DRUG;CYT387, >=98%;Benzamide,N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-;CYT 11387;CYT 387;N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide;LM-1149;CYT 387(CYT 11387)
CAS: 1056634-68-4
MF: C23H22N6O2
MW: 414.45978
EINECS:  
Product Categories: API;Inhibitors;Anti-cancer;Inhibitor
Mol File: 1056634-68-4.mol
Article illustration
 
Momelotinib Chemical Properties
density  1.292
 
Safety Information
MSDS Information
 
 
Momelotinib Usage And Synthesis
Description Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Phase 3.
In vitro CYT387 inhibits the proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated by IL-3 with IC50 of 1400 nM. Furthermore, CYT387 also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling, including Ba/F3-MPLW515L cells, CHRF-288-11 cells and Ba/F3-TEL-JAK2 cells with IC50 of 200 nM, 1 nM and 700 nM, respectively. In addition, CYT387 has been shown to inhibit erythroid colony growth in vitro from JAK2V617F-positive PV patients with similar potency with IC50 of 2μ-4 μM. A recent study shows that CYT387 inhibits PI3K/AKT and Ras/MAPK signaling induced by IL-6 and IGF-1. Moreover, CYT387 induces apoptosis as a single agent and synergizes with the conventional anti-MM therapies bortezomib and melphalan in primary multiple myeloma (MM) cells.
In vivo In a murine MPN model, CYT387 normalizes white cell counts, hematocrit, spleen size, and restores physiologic levels of inflammatory cytokines.
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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