Product Details
| Product Name:
Pazufloxacin |
CAS No.:
127045-41-4 |
| Min. Order:
1kg |
Purity:
98% |
| Supply Ability:
100kg |
Release date:
2019/07/06 |
| Product Number::
wm1024 |
| Pazufloxacin Basic information |
| Description References |
| Product Name: |
Pazufloxacin |
| Synonyms: |
PAZUFLOXAXIN;T-3761;(s)-yclopropyl)-9-fluoro-3-methyl-7-oxo;Pazufloxacinmyesylate;(3S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID;ALKALYL;Pazufloxaxin mesilate;PAZUFLOXACIN 98+% |
| CAS: |
127045-41-4 |
| MF: |
C16H15FN2O4 |
| MW: |
318.3 |
| EINECS: |
1806241-263-5 |
| Product Categories: |
BacteriostaticAntibiotics;ChinolonesAlphabetic;PA - PENAnalytical Standards;Pharmacology Standards;Antibiotics;Chemical Structure;Chromatography;P;Principle;API's |
| Mol File: |
127045-41-4.mol |
 |
| |
| Pazufloxacin Chemical Properties |
| Melting point |
269-271°C |
| alpha |
D25 -88.0° (c = 0.5 in 0.05N aq NaOH) |
| density |
1.56 |
| storage temp. |
2-8°C |
| CAS DataBase Reference |
127045-41-4(CAS DataBase Reference) |
| Hazard Codes |
Xn,C,F |
| Risk Statements |
20/21/22-34-11 |
| Safety Statements |
36/37-45-36/37/39-26-16 |
| RTECS |
UU8815300 |
| Toxicity |
LD50 i.v. in male mice: >500 mg/kg (Todo) |
| Provider |
Language |
| (3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid |
English |
| |
| Pazufloxacin Usage And Synthesis |
| Description |
Pazufloxacin is a fluoroquinolone with a 1-aminocyclopropyl substituent at C10 position. The presence of aminoacyl group at C-10 is a unique feature of the molecule imparting potent broad spectrum activity against gram-positive and gram-negative bacteria. This activity is based on the inhibition of bacterial DNA gyrase.
Pazufloxacin is used as an injectable antibiotic with bacterial effect against cephalosporin-resistant, carbapenem-resistance, and aminoglycoside resistant strains of bacteria. The adverse effects of pazufloxacin, such as drug-induced convulsion and hypotension are less than those of other conventional injectable fluoroquinolones. |
| References |
[1] A. Vora, Pazufloxacin, tracked from www.japi.org on 16.07.2017
[2] Jeffrey K. Aronson, Meyler’s Side Effects of Antimicrobial Drugs, 2009
[3] Satoshi Watabe, Yoshiaki Yokoyama, Kazuyuki Nakazawa, Kimikazu Shinozaki, Rika Hiraoka, Kei Takeshita and Yukio Suzuki, Simultaneous measurement of pazufloxacin, ciprofloxacin, and levofloxacin in human serum by high-performance liquid chromatography with fluorescence detection, Journal of Chromatography B, 2010, vol. 878, 1555-1561 |
| Uses |
antibactierial |
| |
| Pazufloxacin Preparation Products And Raw materials |
| Raw materials |
Ethyl acetate-->Trifluoroacetic acid-->Sodium sulfite-->Sodium azide-->Paraformaldehyde-->N,N-Dimethylformamide dimethyl acetal-->Dimethyl sulfide-->Methanesulfonic acid-->1,1'-Carbonyldiimidazole-->5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide-->Diphenyldiazomethane-->Ethyl 2,3,4,5-tetrafluorobenzoate-->Di-tert-Butyl malonate |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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