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Oxcarbazepine, sold under the brand name Trileptal among others, is a medication used to treat epilepsy and bipolar disorder. For epilepsy it is used for both focal seizures and generalized seizures. It has been used both alone and as add-on therapy in people with bipolar who have had no success with other treatments. It is taken by mouth.

Common side effects include nausea, vomiting, dizziness, drowsiness, double vision and trouble with walking.[5] Serious side effects may include anaphylaxis, liver problems, pancreatitis, suicide, and an abnormal heart beat. While use during pregnancy may harm the baby, use may be less risky than having a seizure.Use is not recommended during breastfeeding.In those with an allergy to carbamazepine there is a 25% risk of problems with oxcarbazepine. How it works is not entirely clear.