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Postion:Product Catalog >API>Antineoplastic agents>Idiopathic pulmonary fibrosis(IPF)>Pirfenidone
Pirfenidone
  • Pirfenidone

Pirfenidone

Price $1
Package 1g
Min. Order: 1g
Supply Ability: 1000 Kilogram/Kilograms per Week
Update Time: 2019-07-31

Product Details

Product Name: Pirfenidone CAS No.: 53179-13-8
Min. Order: 1g Purity: 99%
Supply Ability: 1000 Kilogram/Kilograms per Week Release date: 2019/07/31

1) Product Name: pirfenidone
2) Testing Method: HPLC
3) Appearance: White crystalline powder
The new anti-fibrotic material, with broad-spectrum anti-lung, liver, kidney, heart, and peritoneal fibrosis

Pirfenidone is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep within your lungs. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen.

The cause of IPF is often unknown, but this condition is a progressive disease that can be fatal. Pirfenidone is not a cure for IPF, but this medicine may slow the progress of this disease.

Pirfenidone may also be used for purposes not listed in this medication guide.

Application

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

Specification

Product name

Pirfenidone

Result of Analysis

Items

Specifications

Results

Appearance

White or almost white crystalline powder

Meets the requirements

Identification

Meets the requirements

Meets the requirements

Melting point

106℃-108℃

107.3℃-108℃

Water (K.F)

Not more than 0.5%

0.09%

2-hydroxy-5-picoline

Not more than 0.15%

None

Any other unspecified

Not more than 0.1%

0.03%

Total impurity

Not more than 0.5%

0.05%

Bromobenzene

Not more than 0.036%

0.01%

Ethyl acetate

Not more than 0.5%

None

Heavy metal

Not more than 20ppm

Less than 20ppm

R0l

Not more than 0.1%

Less than 0.1%

Assay

Not less than 98.0%

99.5%

Conclusion

Comply with the requirements.

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