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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>Sapropterin Hydrochloride
Sapropterin Hydrochloride
  • Sapropterin Hydrochloride

Sapropterin Hydrochloride

Price $3
Package 3KG
Min. Order: 1KG
Supply Ability: 100kg
Update Time: 2019-08-07

Product Details

Product Name: Sapropterin Hydrochloride CAS No.: 69056-38-8
Min. Order: 1KG Purity: 99%
Supply Ability: 100kg Release date: 2019/08/07
Product model: windy
Sapropterin Hydrochloride Basic information
Product Name:
Sapropterin Hydrochloride
Synonyms:
sapropterinhydrochloride;sun0588;6R-BH4;(6R)-BH4 2HCL;[6R-[6R*(1R*,2S*)]]-2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE DIHYDROCHLORIDE;(6R)-5,6,7,8-TETRAHYDRO-BIOPTERIN DIHYDROCHLORIDE;(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE;6-BETA-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
CAS:
69056-38-8
MF:
C9H17Cl2N5O3
MW:
314.17
EINECS:
663-669-3
Product Categories:
Chemical Amines;Amines;Chiral Reagents;Heterocycles;Nitric Oxide Reagents;Nitric Oxide
Mol File:
69056-38-8.mol
Article illustration
 
Sapropterin Hydrochloride Chemical Properties
Melting point 
245-246° (dec)
alpha 
D25 -6.81° (c = 0.665 in 0.1 M HCl)
storage temp. 
−20°C
solubility 
water, oxygen free: soluble19.60 - 20.40mg/mL, clear to slightly hazy, colorless to faintly yellow
CAS DataBase Reference
69056-38-8(CAS DataBase Reference)
 
Safety Information
Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
UO3516500
MSDS Information
 
 
Sapropterin Hydrochloride Usage And Synthesis
Description
Sapropterin hydrochloride is a monoamine biosynthesis enhancer introduced for the treatment of hyperphenylalaninemia.Animal studies indicate that sapropterin hydrochloride increases brain levels of serotonin and enhances the release of acetylcholine from nerve terminals. The compound is also being investigated as a potential cognitive enhancer.
Chemical Properties
White Crystalline Solid
Originator
Suntory (Japan)
Uses
A natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthase. An essential cofactor for the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Increasing
Definition
ChEBI: The dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydrox lase, tryptophan hydroxylase, and nitric oxide synthetase.
Brand name
Biopten
Purification Methods
Recrystallisation of BH4.2HCl from HCl enriches BH4 in the natural 6R isomer. Dissolve the salt (~6g) in conc HCl (15mL) under gentle warming, then add EtOH (30mL) dropwise, chill and collect the colourless needles (67%, up to 99% if the mother liquors are concentrated), and dry it in vacuo immediately over P2O5 and KOH. It is stable indefinitely at -20o in a dry atmosphere. Better store it in sealed ampoules under dry N2. It can be recrystallised from 6N aqueous HCl. It has UV max (in 2N HCl) at 264nm ( 16,770; pH 3.5 phosphate buffer) 265nm ( 13,900); (in pH 7.6) at 297nm ( 9,500) and 260nm sh ( 4,690). It has been separated from the 6S-isomer by HPLC on a Partisil-10SCX column using 30mM ammonium phosphate buffer (pH 3.0) containing 3mM NaHSO3 (2mL/minute flow rate; 275nm detector) with retention times of 5.87minutes (6R) and 8.45minutes (6S). It is stable in acidic solutions and can be stored for extended periods at -20o in 0.04M HCl. Above pH 7 the neutral species are obtained, and these are readily oxidised by the oxygen in the solvent to the quinonoid species, and then further oxidation and degradation occurs at room temperature. These changes are slower at 0o. The sulfate salt can be obtained by recrystallisation from 2M H2SO4 and is less soluble in water than the hydrochloride salt. The 6R-2,5,1',2'-tetraacetylbiopterin derivative has m 292o(dec) after recrystallisation from MeOH (100 parts) and [] 20 -144o (c 0.5, CHCl3), [] 589 +12.8o (c 0.39, Me2SO). [NMR, UV: Matsuura et al. Heterocycles 23 3115 1985, Viscontini et al. Helv Chim Acta 62 2577 1979, Armarego et al. Aust J Chem 37 355 1984, Beilstein 26 III/IV 4032.]
 
Sapropterin Hydrochloride Preparation Products And Raw materials

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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