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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Mitogen-activated protein kinase (MAPK)>MEK inhibitor>TAK-733
TAK-733
  • TAK-733

TAK-733

Price $3
Package 3KG
Min. Order: 1KG
Supply Ability: 100kg
Update Time: 2019-08-07

Product Details

Product Name: TAK-733 CAS No.: 1035555-63-5
Min. Order: 1KG Purity: 99%
Supply Ability: 100kg Release date: 2019/08/07
Product model: windy
TAK-733 Basic information
Description In vitro In vivo
Product Name:
TAK-733
Synonyms:
3-[(2r)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione;TAK-733;TAK-733/TAK733;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione TAK 733;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrim
CAS:
1035555-63-5
MF:
C17H15F2IN4O4
MW:
504.2266764
EINECS:
 
Product Categories:
MAPK;Inhibitors
Mol File:
1035555-63-5.mol
Article illustration
 
TAK-733 Chemical Properties
 
Safety Information
MSDS Information
 
 
TAK-733 Usage And Synthesis
Description
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.
In vitro
TAK-733 is highly potent and selective MEK allosteric site inhibitor with IC50 of 3.2 nM. TAK-733 shows potent enzymatic and cell activity with an EC50 of 1.9 nM against ERK phosphorylation in cells.
In vivo
TAK-733 demonstrates broad antitumor activity in mouse xenograft models of human cancer including models of melanoma, colorectal, NSCLC, pancreatic and breast cancer. TAK-733 is well tolerated with pharmacokinetics and pharmacodynamics that support once-daily oral dosing in humans. TAK-733 shows maximally efficacious doses at once daily orally doses of 10 mg/kg.
 
TAK-733 Preparation Products And Raw materials

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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