Metadoxine
| Price | $3 |
| Package | 3KG |
| Min. Order: | 1KG |
| Supply Ability: | 100kg |
| Update Time: | 2019-08-08 |
Product Details
| Product Name: Metadoxine | CAS No.: 74536-44-0 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: 100kg | Release date: 2019/08/08 |
| Product Model: windy |
Metadoxine
Modify Date: 2019-06-16 16:59:39
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Metadoxine structure
Metadoxine
74536-44-0
298.292
N/A
491.9ºC at 760 mmHg
C13H18N2O6
102-104ºC
N/A
251.3ºC
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Use of Metadoxine
Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.
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4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride (1:1) | dl-proline, 5-oxo-, compd. with n2-coco acyl-l-arginine et ester | (5-hydroxy-6-methyl-3,4-pyridinediyl)bis(methylene) dihexadecanoate | 5-oxo-l-proline - 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol (1: 1) | 4,5-bis(hydroxymethyl)-2-(2h3)methyl-3-pyridinol hydrochloride (1:1)
- Properties
- Spectrum
Names
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Metadoxine
More Synonyms
Metadoxine Biological Activity
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Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA
Signaling Pathways >> Stem Cell/Wnt >> PKA
Research Areas >> Metabolic Disease
Simultaneous Metadoxine treatment notably inhibits adipogenic differentiation in a dose-dependent manner. Metadoxine treatment from day 4 through day 8 is required for inhibition of MDI-induced preadipocyte differentiation[1]. Metadoxine prevents glutathione depletion and the increase in lipid peroxidation damage caused by ethanol and acetaldehyde in HepG2 cells. In hepatic stellate cells, Metadoxine prevents the increase in collagen and attenuated TNF-α secretion caused by acetaldehyde. Thus, Metadoxine could be useful in preventing the damage produced in early stages of alcoholic liver disease as it prevents the redox imbalance of the hepatocytes and prevents TNF-α induction, one of the earliest events in hepatic damage[2].
[1]. Yang YM, et al. Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. Arch Biochem Biophys. 2009 Aug 15;488(2):91-9.
Chemical & Physical Properties
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491.9ºC at 760 mmHg
102-104ºC
C13H18N2O6
298.292
251.3ºC
298.116486
139.98000
Refrigerator
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com