一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Organic Chemistry>Amides>Amides>GSK2982772
GSK2982772
  • GSK2982772

GSK2982772

Price $1
Package 1KG
Min. Order: 1KG
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Update Time: 2019-09-02

Product Details

Product Name: GSK2982772 CAS No.: 1622848-92-3
Min. Order: 1KG Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg Release date: 2019/09/02
Product number: Crystal-Liu
Product Name:
GSK2982772
Synonyms:
1622848-92-3;(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;GSK2982772
CAS:
1622848-92-3
MF:
C20H19N5O3
MW:
377.39656
EINECS:
 
Product Categories:
 
Mol File:
1622848-92-3.mol
Article illustration
 
GSK2982772 Chemical Properties
 
Safety Information
MSDS Information
 
 
GSK2982772 Usage And Synthesis
Description
(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide, also known as GSK2982772, is a first-in-class receptor interacting protein 1(RIP1)-kinase specific clinical candidate for the treatment of inflammatory disease. It is an inhibitor of RIP1 that regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. It has excellent activity in blocking many TNF-dependent cellular responses. Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants. 
References
Harris, P. A., et al. "Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases." Journal of Medicinal Chemistry 60.4(2017):1247-1261.
Jeong, Jae Uk, et al. "Synthesis of ( S )-3-amino-benzo[ b ][1,4]oxazepin-4-one via Mitsunobu and S N Ar reaction for a first-in-class RIP1 kinase inhibitor GSK2982772 in clinical trials." Tetrahedron Letters 58.23(2017):2306-2308.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

Recommended supplier

Product name Price   Suppliers Update time
$68.00
VIP6Y
TargetMol Chemicals Inc.
2026-06-02
  • Since: 2014-12-17
  • Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
楊俊青

sales@coreychem.com
喀什市| 潼关县| 云安县| 昌邑市| 余江县| 大埔县| 长沙县| 咸丰县| 安多县| 阳曲县| 东明县| 平塘县| 宜宾市| 美姑县| 雅安市| 涟源市| 兴文县| 饶平县| 连州市| 渑池县| 高淳县| 固阳县| 中阳县| 报价| 奇台县| 航空| 武汉市| 河池市| 延吉市| 姜堰市| 嘉义市| 内黄县| 南陵县| 浪卡子县| 三门县| 吴桥县| 永平县| 佛学| 长乐市| 方城县| 定陶县|