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Postion:Product Catalog >Organic Chemistry>Amides>Amides>GSK2982772
GSK2982772
  • GSK2982772

GSK2982772

Price $1
Package 1KG
Min. Order: 1KG
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Update Time: 2019-09-02

Product Details

Product Name: GSK2982772 CAS No.: 1622848-92-3
Min. Order: 1KG Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg Release date: 2019/09/02
Product number: Crystal-Liu
Product Name:
GSK2982772
Synonyms:
1622848-92-3;(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;GSK2982772
CAS:
1622848-92-3
MF:
C20H19N5O3
MW:
377.39656
EINECS:
 
Product Categories:
 
Mol File:
1622848-92-3.mol
Article illustration
 
GSK2982772 Chemical Properties
 
Safety Information
MSDS Information
 
 
GSK2982772 Usage And Synthesis
Description
(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide, also known as GSK2982772, is a first-in-class receptor interacting protein 1(RIP1)-kinase specific clinical candidate for the treatment of inflammatory disease. It is an inhibitor of RIP1 that regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. It has excellent activity in blocking many TNF-dependent cellular responses. Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants. 
References
Harris, P. A., et al. "Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases." Journal of Medicinal Chemistry 60.4(2017):1247-1261.
Jeong, Jae Uk, et al. "Synthesis of ( S )-3-amino-benzo[ b ][1,4]oxazepin-4-one via Mitsunobu and S N Ar reaction for a first-in-class RIP1 kinase inhibitor GSK2982772 in clinical trials." Tetrahedron Letters 58.23(2017):2306-2308.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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