Product Name:

Butoconazole nitrate

Synonyms:

(+-)-1-(4-(4-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1h-imidazolem;1-(4-(4-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1h-imidazol(+-)-1h-imidazol;Butoconazole nitrate 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole nitrate;(+-)-1-(4-(p-Chlorophenyl)-2-(;1-(4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl)imidazole nitrate;exelgyn;femstat;gynomyk

CAS:

MF:

C19H18Cl3N3O3S

MW:

474.79

EINECS:

613-721-6

Product Categories:

-;API;Intermediates & Fine Chemicals;Pharmaceuticals

Mol File:

64872-77-1.mol

 

Butoconazole nitrate Chemical Properties

Melting point 

159°C (dec.)

storage temp. 

-20?C Freezer

solubility 

DMSO or DMF: soluble

form 

powder

Merck 

14,1529

InChIKey

ZHPWRQIPPNZNML-UHFFFAOYSA-N

CAS DataBase Reference

64872-77-1(CAS DataBase Reference)

 

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

RTECS 

NI4399500

HS Code 

2933290000

Toxicity

LD50 in mice, male, female rats (mg/kg): >3200, >3200, 1720 orally; >1600, 940, 940 i.p. (Walker)

MSDS Information

 

Butoconazole nitrate Usage And Synthesis

Description

Butoconazole Nitrate is an antifungal imidazole antimycotics. It is useful in the topical treatment of vulvovaginal candidiasis, being similar in effectiveness to miconazole and clotrimazole.

Chemical Properties

White Solid

Originator

Syntex (USA)

Uses

Imidazole derivative with antifungal properties

Definition

ChEBI: An organic nitrate salt obtained by reaction of equimolar amounts of butaconazole and nitric acid. An antifungal agent, it is used in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida a bicans.

Brand name

Femstat (Roche);Femstat 3 (Bayer); Gynazole-1 (KV Pharmaceutical).

Clinical Use

1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)-thio]butyl]-1H-imidazole (Femstat) is an extremely broad-spectrum antifungaldrug that is specifically effective against C. albicans.It is supplied as a vaginal cream containing 2% of thesalt. It is intended for the treatment of vaginal candidiasis.