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Postion:Product Catalog >API>Inhibitors>Ponatinib Hydrochloride
Ponatinib Hydrochloride
  • Ponatinib Hydrochloride

Ponatinib Hydrochloride

Price $1
Package 1KG
Min. Order: 1KG
Supply Ability: 1KG;5KG 10KG; 100KG
Update Time: 2019-09-03

Product Details

Product Name: Ponatinib Hydrochloride CAS No.: 1114544-31-8
Min. Order: 1KG Purity: 95.0-99.8%
Supply Ability: 1KG;5KG 10KG; 100KG Release date: 2019/09/03
Product number: Crystal-liu
Product Name:
Ponatinib Hydrochloride
Synonyms:
AP24534 Mono-hydrochloride;Ponatinib Mono-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride;Ponatinib hydrochloride;Ponatinib-HCl;AP24534-HCl;1114544-31-8
CAS:
1114544-31-8
MF:
C29H28ClF3N6O
MW:
569.02
EINECS:
1592732-453-0
Product Categories:
 
Mol File:
1114544-31-8.mol
Article illustration
 
Ponatinib Hydrochloride Chemical Properties
 
Safety Information
MSDS Information
 
 
Ponatinib Hydrochloride Usage And Synthesis
Description
In December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr–Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr– AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.
Originator
Ariad (United States)
Brand name
Iclusig

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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