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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Stem Cells & Wnt>Hedgehog / Smoothened antagonist>pf-5274857
pf-5274857
  • pf-5274857

pf-5274857

Price $1
Package 1KG
Min. Order: 1KG
Update Time: 2019-09-06

Product Details

Product Name: pf-5274857 CAS No.: 1373615-35-0
EC-No.: 200-204-2 Min. Order: 1KG
Purity: 95%~99% Supply Ability: per week 100kg
Release date: 2019/09/06
Mary031
pf-5274857 Basic information
Product Name:
pf-5274857
Synonyms:
pf-5274857;1-(4-(5-chloro-4-(3,5-diMethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(Methylsulfonyl)propan-1-one;1-[4-(5′-Chloro-3,5-dimethyl-2,4′-bipyridin-2′-yl)piperazin-1-yl] -3- (methylsulfonyl)propan-1-one hydrochloride;PF-5274857 hydrochloride;1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-1-piperazinyl]-3-(methylsulfonyl)-1-propanone;1-(4-(5-Chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)prop
CAS:
1373615-35-0
MF:
C20H25ClN4O3S
MW:
436.9555
EINECS:
-0
Product Categories:
-;Inhibitors
Mol File:
1373615-35-0.mol
Article illustration
 
pf-5274857 Chemical Properties
storage temp. 
room temp
solubility 
H2O: soluble3mg/mL, clear (warmed)
form 
powder
color 
white to beige
 
Safety Information
WGK Germany 
3
MSDS Information
 
 
pf-5274857 Usage And Synthesis
Enzyme inhibitor
This brain-penetrating Smoothened (Smo) antagonist (FW = 436.96 g/mol; CAS 1373615-35-0), also known as 1-(4-(5-chloro-4-(3,5-dimethylpyridin- 2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one, potentlyand selectively inhibits Hedgehog (Hh) signaling (IC50 = 5.8 nM; Ki = 4.6 nM). PF-5274857 elicits robust antitumor activity in a mouse model of medulloblastoma (IC50 = 8.9 nmol/L), with down-regulation of Gli1, a marker closely linked to the tumor growth inhibition in patched (+/-) medulloblastoma mice. PF-5274857 also inhibits Smo activity within the brain of primary medulloblastoma mice, improving survival. PF-5274857 is orally available and metabolically stable in vivo. Other Hedgehog inhibitors include: GANT61, BMS-833923, Purmorphamine, SANT-1, LY2940680, Cyclopamine, LDE225 (or NVP-LDE225, Erismodegib), Vismodegib (GDC-0449)
 
pf-5274857 Preparation Products And Raw materials

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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