Mitoxantrone
| Price | $1 |
| Package | 1ASSAYS |
| Min. Order: | 1ASSAYS |
| Update Time: | 2019-09-11 |
Product Details
| Product Name: Mitoxantrone | CAS No.: 65271-80-9 |
| EC-No.: 1533716-785-6 | Min. Order: 1ASSAYS |
| Purity: 95%~99% | Supply Ability: per week 100kg |
| Release date: 2019/09/11 |
Mary052
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Mitoxantrone Basic information
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Product Name:
Mitoxantrone
Synonyms:
MITOXANTRONE;1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedi;1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione;MitoxantroneBase;Mitoxantrone Hcl 70476-82-3 / Base;PharmasubstanceEP4;1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione;NSC-27983
CAS:
65271-80-9
MF:
C22H28N4O6
MW:
444.48
EINECS:
1533716-785-6
Product Categories:
Pharmaceutical material and intermeidates;Intermediates & Fine Chemicals;Pharmaceuticals;Anti-cancer&immunity;Inhibitors
Mol File:
65271-80-9.mol
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Mitoxantrone Chemical Properties
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Melting point
170-1740C
Boiling point
554.47°C (rough estimate)
density
1.3049 (rough estimate)
refractive index
1.6500 (estimate)
storage temp.
-20°C Freezer
pka
pKa 5.99 (Uncertain);8.13 (Uncertain)
CAS DataBase Reference
65271-80-9(CAS DataBase Reference)
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Safety Information
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Hazard Codes
T,T+
Risk Statements
46-61-26/27/28
Safety Statements
53-36/37/39-45-22
WGK Germany
3
RTECS
CB5748500
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MSDS Information
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Mitoxantrone Usage And Synthesis
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Chemical Properties
Dark Blue Crystalline Solid
Uses
A DNA intercalating drug. Inhibits DNA synthesis. Used as an anti-cancer agent
Uses
Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.
Indications
Mitoxantrone (Novantrone) is a synthetic anthraquinone that is structurally and mechanistically related to the anthracyclines. It intercalates with DNA and produces single- strand DNA breakage. It is cross-resistant with doxorubicin in multidrug-resistant cells and in patients who have failed to respond to doxorubicin therapy.
Mitoxantrone is active against breast carcinomas, leukemias, and lymphomas. Its antitumor efficacy in patients with breast cancer is slightly lower than that of doxorubicin. Its major toxicity is myelosuppression; mucositis and diarrhea also may occur. Mitoxantrone produces less nausea, alopecia, and cardiac toxicity than does doxorubicin.
Mitoxantrone is active against breast carcinomas, leukemias, and lymphomas. Its antitumor efficacy in patients with breast cancer is slightly lower than that of doxorubicin. Its major toxicity is myelosuppression; mucositis and diarrhea also may occur. Mitoxantrone produces less nausea, alopecia, and cardiac toxicity than does doxorubicin.
Brand name
Novantrone (Serono).
Veterinary Drugs and Treatments
Mitoxantrone may be useful in the treatment of several neoplastic diseases in dogs and cats, including lymphosarcoma mammary adenocarcinoma, squamous cell carcinoma, renal adenocarcinoma, fibroid sarcoma, thyroid or transitional cell carcinomas, and hemangiopericytoma.
Because renal clearance of the drug is minimal (10%), it may be administered to cats with renal insufficiency much more safely than doxorubicin.
Because renal clearance of the drug is minimal (10%), it may be administered to cats with renal insufficiency much more safely than doxorubicin.
Aroma threshold values
Detection: 0.007 to 205 ppb
Taste threshold values
Taste characteristics art 10 ppm: woody, sweet, fruity, berry-like with a green berry background
General Description
Colorless to light yellow liquid with an odor of cedar wood. In very dilute alcoholic solution the odor resembles odor of violets. Used in perfumery.
Air & Water Reactions
Slightly water soluble .
Reactivity Profile
Irisone may react vigorously with oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic. May cause allergic reaction.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com