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Postion:Product Catalog >API>Hormones and the Endocrine System>Estrogen and progestin drugs> Estradiol 17-Valerate
 Estradiol 17-Valerate
  •  Estradiol 17-Valerate
  •  Estradiol 17-Valerate
  •  Estradiol 17-Valerate
  •  Estradiol 17-Valerate
  •  Estradiol 17-Valerate

Estradiol 17-Valerate

Price Get Latest Price
Package 1KG
Min. Order: 1g
Supply Ability: 1 ton
Update Time: 2021-03-17

Product Details

Product Name: Estradiol 17-Valerate CAS No.: 979-32-8
Min. Order: 1g Purity: 99.9%
Supply Ability: 1 ton Release date: 2021/03/17

簡介

Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Altadiol, Deladiol, Delestrogen, Estraval, Lastrogen, Progynova, Valergen, many others), or oestradiol valerate (BAN), is a synthetic ester, specifically the 17-pentanoyl ester, of the natural estrogen, 17β-estradiol. It was first introduced, as Delestrogen by Squibb in the United States, in 1954, and along with estradiol benzoate (1936) and estradiol cypionate (1952), has since become one of the most widely used esters of estradiol.
Upon ingestion, regardless of the route of administration, estradiol valerate behaves as a prodrug, being cleaved by esterases in blood plasma and the liver into 17β-estradiol and valeric acid. However, compared to estradiol itself, estradiol valerate is absorbed more slowly and possesses a longer duration, especially when given in an oil solution via intramuscular injection (in which it acts as a depot). As a result, it can be administered less frequently.
A single intramuscular injection of 4mg estradiol valerate results in maximal plasma levels of estradiol of about 390 pg/mL within three days of administration, with levels declining to 100 pg/mL by 12–13 days. A study of high-dose combined administration of 40mg estradiol valerate and 250mg hydroxyprogesterone caproate in women once weekly for six months (described as a "pseudopregnancy" regimen) found that serum levels of estradiol increased from 27.8–34.8 pg/mL to 3028–3226 pg/mL after three months and to 2491–2552 pg/mL after six months of treatment.

基本信息

中文名稱
戊酸雌二醇
英文名稱
Estradiol 17-Valerate
中文別名

17-戊酸-Beta-雌二醇酯; 17-戊酸-β-雌二醇酯; 3,5(10)-三烯-17B-醇 17-戊酸酯; 17-戊酸-17-BETA-雌二酯; 3-羥基雌甾-1,3,5(10)-三烯-17b-醇 17-戊酸酯;

英文別名

Estradiol valerate;

CAS號
979-32-8
分子式
C23H32O3
分子量
356.49800
精確質(zhì)量
356.23500
PSA
46.53000
LOGP
5.35030

物化性質(zhì)

密度:
1.13g/cm3
沸點:
486.2ºC at 760mmHg
熔點:
144°C
閃點:
191.1ºC
折射率:
1.567

安全信息

RTECS號:
KG5793000
安全說明:
S53-S45
危險類別碼:
R60; R61
WGK Germany:
3
危險品標(biāo)志:
T

 Article illustrationArticle illustrationArticle illustrationArticle illustrationArticle illustrationArticle illustration

Company Profile Introduction

Welcome to hebei Shuoxi biotechnology co., LTD. Shuoxi is a fast developing pharmaceutical intermediates enterprise located in shijiazhuang, capital of hebei province. Shuoxi analysis research and development center also provides custom synthesis service. Hebei Shuoxi biotechnology co., LTD can provide customized synthetic chemicals in different quantities in laboratories, factories and industrial scale. We have more than 10 years experience in this field. We can offer competitive price for every customer and guarantee the quality of our products. 3. We pay attention to the needs of each customer and build a good relationship with them. 4. We have long-term business relations with Canada, Mexico, Brazil, UK, Russia, Germany, USA, India, South Africa, Malta, Egypt, Armenia, Australia, Philippines, Belgium, Netherlands, Denmark and other countries. If you have any other questions for me. Please feel free to contact me. We only produce and sell products that are legal in China. All products are sold only to laboratory research.

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