UK-371804
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2019-12-23 |
Product Details
| Product Name: UK-371804 | CAS No.: 256477-09-5 |
| Min. Order: 1g | Purity: 99.99% |
| Supply Ability: 200kg | Release date: 2019/12/23 |
Mary
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Product Name:
UK-371804
Synonyms:
UK-371804;Urokinase inhibitor 1;Urokinase inhitibor 1;UK-371804 (Urokinase inhitibor 1)
CAS:
256477-09-5
MF:
C14H16ClN5O4S
MW:
385.82594
EINECS:
-0
Product Categories:
Mol File:
256477-09-5.mol
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UK-371804 Chemical Properties
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CAS DataBase Reference
256477-09-5
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Safety Information
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MSDS Information
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UK-371804 Usage And Synthesis
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Description
UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.
References
http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
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UK-371804 Preparation Products And Raw materials
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Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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