CARUMONAM
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: CARUMONAM | CAS No.: 87638-04-8 |
| Min. Order: 1g | Purity: ≥98% |
| Supply Ability: g/kg/Ton | Release date: 2019/12/26 |
| Delivery Time: Prompt | Packaging: Bottle/Durm/Bag |
| Transportation: By air/Bay Sea/Express |
Heidi 0663
Email:heidi@coreychem.com
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CARUMONAM Basic information
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Product Name:
CARUMONAM
Synonyms:
Acetic acid, [[[2-[[2-[[(aminocarbonyl)oxy]methyl]-4-oxo-1-sulfo-3-azetidinyl]amino]-1-(2-amino-4-thiazolyl)-2-oxoethylidene]amino]oxy]-, [2S-[2α,3α(Z)]]-;AMA 1080;Antibiotic Ro 17-2301;Ro 17-2301;[2S-[2α，3α(Z)]]-[[[2-[[2-[[(Aminocarbonyl)oxy]methyl]-4-oxo-1-sulfo-3-azetidinyl]amino]-1-(2-amino-4-thiazolyl)-2-oxoethylidene]amino]oxy]acetic acid;CarlliIIonaln;Ro-17-2301：A-masulin;(2S)-2α-(Carbamoyloxymethyl)-3α-[[(Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-4-oxoazetidine-1-sulfonic acid
CAS:
87638-04-8
MF:
C12H14N6O10S2
MW:
466.4
EINECS:
Product Categories:
Mol File:
87638-04-8.mol
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CARUMONAM Chemical Properties
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alpha
D26 -45° (c = 1 in DMSO)
density
2.13±0.1 g/cm3(Predicted)
pka
-0.43±0.60(Predicted)
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Safety Information
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MSDS Information
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CARUMONAM Usage And Synthesis
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Description
Canunonam is an injectable antibiotic, the second monobactam ever developed (the first being Squibb’s aztreonam). It is highly active against Gram negative bacteria, particularly pseudomom, and is reportedly effective in the treatment of pneumonia, cystitis, peritonitis and secondary infections.
Originator
Takeda (Japan)
Definition
ChEBI: An N-sulfonated monobactam antibiotic.
Brand name
Amasulin
Antimicrobial activity
A synthetic monobactam with activity against common pathogenic organisms similar to that of aztreonam. It is resistant to hydrolysis by the common plasmid and chromosomal β-lactamases, but it can be hydrolyzed by ESBLs.
It is administered intravenously, achieving a concentration of c. 78 mg/L after a 20-min infusion of 1 g. The plasma halflife is 1.7 h and the plasma protein binding 18–28%. Carumonam is almost entirely eliminated in the glomerular filtrate, probenecid having no effect on excretion; 96% of labeled compound is found in the urine, with 3% in the feces. Between 68% and 91% of the dose appears in the urine within 24 h.
Side effects and clinical use are similar to those of aztreonam.
It is administered intravenously, achieving a concentration of c. 78 mg/L after a 20-min infusion of 1 g. The plasma halflife is 1.7 h and the plasma protein binding 18–28%. Carumonam is almost entirely eliminated in the glomerular filtrate, probenecid having no effect on excretion; 96% of labeled compound is found in the urine, with 3% in the feces. Between 68% and 91% of the dose appears in the urine within 24 h.
Side effects and clinical use are similar to those of aztreonam.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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