HERBIMYCIN A
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: HERBIMYCIN A | CAS No.: 70563-58-5 |
| Min. Order: 1g | Purity: ≥98% |
| Supply Ability: g/kg/Ton | Release date: 2019/12/26 |
| Delivery Time: Prompt | Packaging: Bottle/Durm/Bag |
| Transportation: By air/Bay Sea/Express |
Heidi 0701
Email:heidi@coreychem.com
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HERBIMYCIN A Basic information
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Product Name:
HERBIMYCIN A
Synonyms:
antibiotictan420f;herbimycin;HERBIMYCIN A;HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS;HERBIMYCIN A, STREPTOMYCES SPECIES;herbimycin A from streptomyces hygros-copicus;herbimycin A from streptomyces*hygroscopicus;Herbimycin A, Streptomyces sp.
CAS:
70563-58-5
MF:
C30H42N2O9
MW:
574.66
EINECS:
Product Categories:
Heat Shock Protein 90;Antibiotic
Mol File:
70563-58-5.mol
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HERBIMYCIN A Chemical Properties
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Melting point
229-231 °C
Boiling point
752℃
density
1.19±0.1 g/cm3(Predicted)
Fp
>110°(230°F)
storage temp.
−20°C
solubility
DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
pka
8.56±0.70(Predicted)
form
powder
color
yellow
Sensitive
Light Sensitive & Hygroscopic
BRN
4834067
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Safety Information
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Hazard Codes
Xi
Risk Statements
36/37/38
Safety Statements
22-24/25-36-26
WGK Germany
3
RTECS
LX8930000
F
10-21
HS Code
29419000
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MSDS Information
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Provider
Language
SigmaAldrich
English
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HERBIMYCIN A Usage And Synthesis
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Uses
Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kDa heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including certain steroid hormone receptors and select kinases. Herbimycin also inhibits protein tyrosine kinase and angiogenesis.
Uses
Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces. It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90. Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf. Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites. Ansamycins, including herbimycin A and geldanamycin , bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.
Definition
ChEBI: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.
Biological Activity
Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL . Exhibits antiangiogenic activity in endothelial cells in vitro . Also inhibits Hsp90 and impairs recovery from heat shock.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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