(-)PPP
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2019-12-31 |
Product Details
| Product Name: (-)PPP | CAS No.: 477-47-4 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 200kg | Release date: 2019/12/31 |
Mary
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Product Name:
(-)PPP
Synonyms:
IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem;AXL 1717;AXL1717;AXL-1717;(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;Picropodophyllotoxin, >=98%;PICROPODOPHYLLIN;(-)PPP
CAS:
477-47-4
MF:
C22H22O8
MW:
414.40528
EINECS:
Product Categories:
Picropodophyllin;Insulin-like Growth Factor-1 Receptor Inhibitor
Mol File:
477-47-4.mol
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(-)PPP Chemical Properties
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Melting point
225-227℃
alpha
D20 +9.4° (c = 0.7 in chloroform)
Boiling point
453.31°C (rough estimate)
density
1.370
refractive index
1.4480 (estimate)
storage temp.
2-8°C
solubility
H2O: soluble
pka
13.26±0.40(Predicted)
form
powder
color
white
Sensitive
Light Sensitive
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Safety Information
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Hazard Codes
Xi,T
Risk Statements
36/37/38-68-25-21
Safety Statements
26-36-45-36/37
RIDADR
UN 3462 6.1/PG 2
WGK Germany
3
RTECS
LV2510000
HazardClass
6.1
Toxicity
LD50 intraperitoneal in mouse: 280mg/kg
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MSDS Information
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Provider
Language
SigmaAldrich
English
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(-)PPP Usage And Synthesis
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Uses
Insulin growth factor 1 receptor inhibitor, antineoplastic
Definition
ChEBI: An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.
Biological Activity
Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo .
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(-)PPP Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: 702, Building 10, East District, National University Science and Technology Park, High tech Zone, Zh
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