BAY 11-7085
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2019-12-31 |
Product Details
| Product Name: BAY 11-7085 | CAS No.: 196309-76-9 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 200kg | Release date: 2019/12/31 |
Mary
▼
▲
Product Name:
BAY 11-7085
Synonyms:
(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE;(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE;BAY 11-7085;(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile;BAY 117083;(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile BAY 11-7085;BAY 11-7085 - CAS 196309-76-9 - Calbiochem;BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
CAS:
196309-76-9
MF:
C13H15NO2S
MW:
249.33
EINECS:
Product Categories:
Cytokine signaling;Inhibitors
Mol File:
196309-76-9.mol
▼
▲
BAY 11-7085 Chemical Properties
▼
▲
Melting point
80-82℃
density
1.144
Fp
200℃
storage temp.
Store at +4°C
solubility
DMSO: >25 mg/mL, soluble
form
solid
color
white
Sensitive
Light Sensitive
InChIKey
VHKZGNPOHPFPER-ONNFQVAWSA-N
CAS DataBase Reference
196309-76-9
▼
▲
Safety Information
▼
▲
WGK Germany
3
RTECS
UD1312500
HS Code
29309090
▼
▲
MSDS Information
▼
▲
Provider
Language
SigmaAldrich
English
▼
▲
BAY 11-7085 Usage And Synthesis
▼
▲
Uses
In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.
Biological Activity
Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .
▼
▲
BAY 11-7085 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
You may like
![1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane](https://img.chemicalbook.com/ProductImageEN/2020-1/Large/3968bd20-9ad4-4aa2-bdae-a62c660e2296.png)
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $30.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-06-01 | |
| $793.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-05-27 | |
| $2530.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-05-11 | |
| $43.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-05-11 |
China- Since: 2014-12-17
- Address: 702, Building 10, East District, National University Science and Technology Park, High tech Zone, Zh
INQUIRY