Mezlocillin
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | 10000KGS |
| Update Time: | 2020-01-01 |
Product Details
| Product Name: Mezlocillin | CAS No.: 51481-65-3 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: 10000KGS | Release date: 2020/01/01 |
hanne 774
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Product Name:
Mezlocillin
Synonyms:
(2s-(2-alpha,5-alpha,6-beta)(s*))-sodiumsal;4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-6-(((((3-(met;3,3-dimethyl-7-[[2-[(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino]-2-phenyl-acetyl]amino]-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid;MEZLOCILLIN;Melocillin sodium;antibioticbay-f1353;Meloxacam acid;Mezlocillin acid
CAS:
51481-65-3
MF:
C21H25N5O8S2
MW:
539.58
EINECS:
257-233-8
Product Categories:
-
Mol File:
51481-65-3.mol
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Mezlocillin Chemical Properties
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density
1.63±0.1 g/cm3(Predicted)
pka
pKa 2.7 (Uncertain)
CAS DataBase Reference
51481-65-3(CAS DataBase Reference)
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Safety Information
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MSDS Information
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Mezlocillin Usage And Synthesis
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Uses
Antibacterial.
Definition
ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.
Brand name
Multocillin (Bayer).
Antimicrobial activity
A semisynthetic acylureidopenicillin supplied as the sodium salt for parenteral administration.
Ampicillin-susceptible strains of H. influenzae and Neisseria spp. are very susceptible, but β-lactamase-producing organisms are usually resistant. It is less active than azlocillin and piperacillin against Ps. aeruginosa and has variable activity against B. fragilis, independent of β-lactamase production. It exhibits typical β-lactam synergy with aminoglycosides against Ps. aeruginosa and enterobacteria.
It attains peak concentrations of 250 mg/L after a 2 g intravenous infusion, with a plasma half-life of 55 min. Protein binding is 20–30%. It distributes into multiple tissues and human body fluids at therapeutically useful concentrations. Up to 60% of the dose is recoverable unchanged from the urine, with up to 2.5% excreted in the bile.
Toxicity and side effects are similar to those associated with carboxypenicillins. Its clinical use is for serious infections with susceptible organisms, including lower respiratory tract, intra-abdominal, urinary tract and gynecological infections. Commercial availability is quite limited.
Ampicillin-susceptible strains of H. influenzae and Neisseria spp. are very susceptible, but β-lactamase-producing organisms are usually resistant. It is less active than azlocillin and piperacillin against Ps. aeruginosa and has variable activity against B. fragilis, independent of β-lactamase production. It exhibits typical β-lactam synergy with aminoglycosides against Ps. aeruginosa and enterobacteria.
It attains peak concentrations of 250 mg/L after a 2 g intravenous infusion, with a plasma half-life of 55 min. Protein binding is 20–30%. It distributes into multiple tissues and human body fluids at therapeutically useful concentrations. Up to 60% of the dose is recoverable unchanged from the urine, with up to 2.5% excreted in the bile.
Toxicity and side effects are similar to those associated with carboxypenicillins. Its clinical use is for serious infections with susceptible organisms, including lower respiratory tract, intra-abdominal, urinary tract and gynecological infections. Commercial availability is quite limited.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: 702, Building 10, East District, National University Science and Technology Park, High tech Zone, Zh
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