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Postion:Product Catalog >Organic Chemistry>Phosphines>NERIDRONATE SODIUM HYDRATE
NERIDRONATE SODIUM HYDRATE
  • NERIDRONATE SODIUM HYDRATE

NERIDRONATE SODIUM HYDRATE

Price $1
Package 1KG
Min. Order: 1KG
Supply Ability: 1ton
Update Time: 2020-01-05

Product Details

Product Name: NERIDRONATE SODIUM HYDRATE CAS No.: 79778-41-9
EC-No.: 200-258-5 Min. Order: 1KG
Purity: 95--99% Supply Ability: 1ton
Release date: 2020/01/05
contact: flora@coreychem.com
NERIDRONATE SODIUM HYDRATE Basic information
Product Name:
NERIDRONATE SODIUM HYDRATE
Synonyms:
6-amino-1-hydroxyhexane-1,1-diphosphonate;Neridronic;6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia;(6-AMino-1-hydroxyhexane-1,1-diyl)diphosphonic acid;Phosphonic acid,P,P'-(6-aMino-1-hydroxyhexylidene)bis-;6-amino-1-hydroxyhexane-1,1-diphosphonic acid;6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID;NERIXIA
CAS:
79778-41-9
MF:
C6H17NO7P2
MW:
277.15
EINECS:
 
Product Categories:
 
Mol File:
79778-41-9.mol
Article illustration
 
NERIDRONATE SODIUM HYDRATE Chemical Properties
Melting point 
245°
Boiling point 
600.1±65.0 °C(Predicted)
density 
1.658±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: 8 mg/mL, soluble
pka
1.93±0.10(Predicted)
form 
solid
color 
white
 
Safety Information
Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
MSDS Information
Provider
Language
SigmaAldrich
English
 
NERIDRONATE SODIUM HYDRATE Usage And Synthesis
Description
Neridronic acid was launched in Italy as intravenous or intramuscular injection for the treatment of osteogenesis imperfecta. It is the first drug launched worldwide for this “orphan disease” characterized by a fragility of the bone. Sufferers risk frequent fractures commencing during infancy, eventually leading to bone deformation and a severe deterioration of the quality of life and life expectancy. Neridronic acid is structurally related to the second generation of bisphosphonates characterized by an amino terminal group and can be synthesized by treating E-aminocaproic acid with phosphoric acid and phosphorous trichloride. Bisphosphonates, synthetic analogs of the endogenous mineral deposition inhibitor pyrophosphate, are extremely potent inhibitors of bone resorption and increase bone mineral density, possibly by inhibiting the activity of osteoclasts and promoting the death of these bone-eroding cells. In vitro, neridronic acid was a poor inhibitor of phagocytosis, but significantly and dose dependently inhibited 8glucuronidase release and superoxide anion production in the rat peritoneal macrophage, two parameters that may have a part in bone resorption. In a clinical study on patients with osteogenesis imperfecta, neridronic acid increased remarkably bone mass in young growing individuals. In adults the changes were less important but still significant.
Originator
lnstituto Gentili (Italy)

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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